Description

4-Hydroxy Propranolol HCl is a key metabolite and reference standard of the widely used β-blocker, Propranolol. This compound is essential for pharmaceutical research and development, particularly in pharmacokinetic studies, metabolic pathway analysis, and analytical method validation. It is primarily utilized by pharmaceutical manufacturers, contract research organizations (CROs), and academic institutions engaged in cardiovascular drug development and bioanalytical testing.

Application

• Pharmaceutical Reference Standard: Serves as a certified standard for the quantification of Propranolol and its metabolites in drug substance and finished product analysis.
• Metabolite Research: Critical for studying the metabolic fate, bioavailability, and clearance pathways of Propranolol in preclinical and clinical research.
• Analytical Method Development: Used to develop and validate HPLC, LC-MS, and other chromatographic methods for impurity profiling and assay determination.
• Pharmacokinetic Studies: Employed in ADME (Absorption, Distribution, Metabolism, Excretion) studies to understand drug behavior in biological systems.
• Quality Control Laboratories: Acts as a system suitability and identification marker in the quality control of Propranolol active pharmaceutical ingredients (APIs).
• Toxicology and Safety Assessment: Used in studies to evaluate the safety profile and potential toxicity of Propranolol metabolites.

Basic Information

Product Name	4-Hydroxy Propranolol HCl
CAS No.	14133-90-5
Molecular Formula	C₁₆H₂₂ClNO₃
Molecular Weight	311.80 g/mol
Synonyms	1-(Isopropylamino)-3-(naphthalen-1-yloxy)propan-2-ol Hydrochloride; 4-Hydroxypropranolol Hydrochloride; Propranolol Metabolite 4-Hydroxy HCl; 1-(1-Methylethylamino)-3-(1-naphthalenyloxy)-2-propanol Hydrochloride; 4-OH-Propranolol HCl; (±)-4'-Hydroxypropranolol Hydrochloride
EINECS	Contact for details

Quality Control

Our 4-Hydroxy Propranolol HCl is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including identification, purity assay, and impurity profiling via HPLC and other pharmacopeial methods, to ensure it meets the high standards required for reference material applications. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming compliance with specified parameters.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept in a dry environment. For long-term storage, consider desiccants or inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Related Substances (HPLC)	Individual impurity ≤0.5%; Total impurities ≤1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.