Description

Ac-Trp-Onp CAS NO 14009-92-8 is a protected amino acid derivative, specifically N-Acetyl-L-tryptophan p-nitrophenyl ester. This compound serves as a crucial building block in peptide synthesis, offering a reactive ester group for efficient amide bond formation. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel peptides, peptidomimetics, and biochemical probes.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key reagent for the controlled incorporation of tryptophan residues into peptide chains.
• Solution-Phase Peptide Coupling: Used in classical peptide synthesis methodologies for fragment condensation.
• Bioconjugation: Facilitates the attachment of peptides or tryptophan-containing motifs to other molecules, surfaces, or biomacromolecules.
• Pharmaceutical Intermediate: Serves as a critical intermediate in the research and development of therapeutic peptides and related active pharmaceutical ingredients (APIs).
• Biochemical Research: Employed in enzymatic studies and as a substrate analog for proteases and other enzymes.
• Material Science: Used in the synthesis of specialized polymers and smart materials with peptide-based functionalities.

Basic Information

Product Name	Ac-Trp-Onp CAS NO 14009-92-8
CAS No.	14009-92-8
Molecular Formula	C21H19N3O6
Molecular Weight	409.39 g/mol
Synonyms	N-Acetyl-L-tryptophan p-nitrophenyl ester; N-Acetyl-L-tryptophan 4-nitrophenyl ester; N-Acetyltryptophan p-nitrophenyl ester; Ac-Trp-ONp; Ac-L-Trp-ONp; N-α-Acetyl-L-tryptophan 4-nitrophenyl ester; (S)-2-Acetamido-3-(1H-indol-3-yl)propanoic acid 4-nitrophenyl ester
EINECS	Contact for details

Quality Control

Our Ac-Trp-Onp is manufactured under strict quality control protocols to ensure high purity and batch-to-batch consistency, suitable for demanding research and development applications. Each lot is analyzed using advanced techniques including HPLC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, chiral purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and reactivity. Allow the sealed container to reach room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% (L-isomer)
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Single Unknown Impurity (HPLC)	≤0.5%
Total Impurities (HPLC)	≤2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.