Description

3-Nitro-n-Acetyl-L-Tyrosine is a chemically modified derivative of the amino acid L-tyrosine, featuring both nitro and acetyl functional groups. This compound is a crucial synthetic intermediate and research chemical, valued for its role in advanced organic synthesis and biochemical studies. It is primarily utilized by pharmaceutical R&D laboratories, academic research institutions, and fine chemical manufacturers engaged in peptide chemistry and the development of enzyme inhibitors or signaling pathway modulators.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of more complex bioactive molecules and potential drug candidates.
• Biochemical Research: Used as a substrate or inhibitor in enzymatic studies, particularly those involving tyrosine kinases or phosphatases.
• Peptide Chemistry: Serves as a modified tyrosine residue for the incorporation of nitro-aromatic motifs into synthetic peptides for structure-activity relationship (SAR) studies.
• Proteomics & Labeling: Potential use in the development of chemical probes for labeling and detecting specific proteins or enzymes in complex biological systems.
• Reference Standard: Employed as an analytical standard in quality control laboratories for method development and validation.
• Academic Synthesis: A teaching compound in advanced university laboratories for demonstrating electrophilic aromatic substitution and protecting group chemistry.

Basic Information

Product Name	3-Nitro-n-Acetyl-L-Tyrosine
CAS No.	13948-21-5
Molecular Formula	C₁₁H₁₂N₂O₆
Molecular Weight	268.22 g/mol
Synonyms	N-Acetyl-3-nitro-L-tyrosine; (2S)-2-Acetamido-3-(4-hydroxy-3-nitrophenyl)propanoic acid; 3-Nitro-N-acetyltyrosine; L-Tyrosine, N-acetyl-3-nitro-; Acetyl-3-nitrotyrosine; 3-Nitroacetyltyrosine; 3-NAT; N-Acetyl-3-nitrotyrosine
EINECS	Contact for details

Quality Control

Our 3-Nitro-n-Acetyl-L-Tyrosine is manufactured under a strict quality management system. Every batch undergoes comprehensive analytical testing, including HPLC for purity assessment and spectroscopic methods for identity confirmation, to ensure it meets the high standards required for research and synthesis. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting batch-specific results for purity, identity, and related substances.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). The product is light-sensitive and should be handled accordingly to maintain stability.

Specification

Item	Specification
Appearance	Yellow to light brown crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Specific Rotation	-10° to -15° (c=1 in DMF)
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.