Description

n-[(Benzyloxy)Carbonyl]-L-Leucine Pentachlorophenyl Ester is a specialized, high-purity amino acid derivative used as a key building block in peptide synthesis. This compound matters for its role as an activated ester, facilitating efficient and selective amide bond formation under mild conditions, which is critical for producing complex peptides with high fidelity. It is primarily needed by research institutions and pharmaceutical companies engaged in the development of therapeutic peptides, peptidomimetics, and biochemical probes.

Application

• Solid-Phase Peptide Synthesis (SPPS): As an activated amino acid derivative for the sequential coupling of leucine residues.
• Solution-Phase Peptide Synthesis: For the controlled synthesis of peptide fragments and small oligopeptides.
• Bioconjugation: Coupling leucine or peptide sequences to other molecules, carriers, or surfaces for creating labeled compounds.
• Pharmaceutical Intermediate: In the research and development of novel peptide-based active pharmaceutical ingredients (APIs).
• Biochemical Research: Synthesis of substrate analogs, enzyme inhibitors, and other tools for proteomics and molecular biology studies.
• Material Science: Potential use in creating functionalized polymers or surfaces with peptide motifs.

Basic Information

Product Name	n-[(Benzyloxy)Carbonyl]-L-Leucine Pentachlorophenyl Ester
CAS No.	13758-71-9
Molecular Formula	C20H20Cl5NO4
Molecular Weight	511.65 g/mol
Synonyms	Z-L-Leu-OPcp; Z-Leu-OPcp; Cbz-L-Leucine Pentachlorophenyl Ester; N-Carbobenzoxy-L-leucine pentachlorophenyl ester; Nα-Cbz-L-leucine pentachlorophenyl ester; L-Leucine, N-[(phenylmethoxy)carbonyl]-, pentachlorophenyl ester; (S)-2-(((Benzyloxy)carbonyl)amino)-4-methylpentanoic pentachlorophenyl ester
EINECS	Contact for details

Quality Control

Our n-[(Benzyloxy)Carbonyl]-L-Leucine Pentachlorophenyl Ester is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity, suitable for sensitive synthetic applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We support compliance with cGMP guidelines for pharmaceutical intermediates and relevant research standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider using a desiccant.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Optical Rotation [α]D20	Contact for details
Melting Point	Contact for details
Heavy Metals	< 10 ppm
Residual Solvents (GC)	Complies with ICH guidelines
Water Content (KF)	< 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.