Description

Boc-o-tert-Butyl-L-Threonine is a high-purity, protected amino acid derivative essential for advanced peptide synthesis. This compound is critical for researchers and manufacturers requiring precise control over stereochemistry and side-chain functionality during solid-phase and solution-phase peptide assembly. It is primarily utilized by the pharmaceutical, biotechnology, and academic research sectors for the development of novel therapeutic peptides, peptidomimetics, and complex bioactive molecules.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of complex peptide-based active pharmaceutical ingredients (APIs) and drug candidates.
• Peptide Synthesis: Used in Fmoc/t-Bu and Boc/Bzl solid-phase peptide synthesis (SPPS) strategies to incorporate L-threonine with orthogonal side-chain protection.
• Research & Development: Enables the study of protein structure-function relationships and the creation of custom peptides for biochemical assays.
• Bioconjugation: Serves as a precursor for creating functionalized peptides for drug delivery systems and diagnostic probes.
• Combinatorial Chemistry: A valuable reagent in libraries for high-throughput screening to discover new bioactive compounds.

Basic Information

Product Name	Boc-o-tert-Butyl-L-Threonine
CAS No.	13734-40-2
Molecular Formula	C₁₃H₂₅NO₅
Molecular Weight	275.34 g/mol
Synonyms	(2S,3R)-2-[(tert-Butoxycarbonyl)amino]-3-[(2-methylpropan-2-yl)oxy]butanoic acid; N-(tert-Butoxycarbonyl)-O-tert-butyl-L-threonine; Boc-Thr(OtBu)-OH; Boc-L-Threonine(O-t-butyl); N-Boc-O-t-butyl-L-threonine; tert-Butyl N-[(1S,2R)-1-(tert-butoxymethyl)-3-carboxy-1-oxopropan-2-yl]carbamate
EINECS	Contact for details

Quality Control

Our Boc-o-tert-Butyl-L-Threonine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis for enantiomeric excess, and NMR for structural confirmation, to ensure it meets the stringent requirements for peptide synthesis. Certificates of Analysis (COA) detailing all specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. The product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.5%
Optical Rotation [α]²⁰D	-15.0° to -18.0° (c=1 in MeOH)
Chiral Purity (HPLC)	≥99.0%
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.