Description

Boc-Ser(Tbu)-Oh is a protected amino acid derivative widely used in peptide synthesis. This compound is essential for building complex peptide chains, as it safeguards the serine side chain hydroxyl group during the coupling process. It is a critical building block for researchers and manufacturers in the pharmaceutical, biotechnology, and life sciences sectors developing therapeutic peptides and other bioactive molecules.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected amino acid for the sequential assembly of peptides on resin.
• Solution-Phase Peptide Synthesis: Used in classical coupling reactions for constructing peptide fragments.
• Pharmaceutical Intermediate: Serves as a crucial raw material in the synthesis of peptide-based active pharmaceutical ingredients (APIs).
• Bioconjugation: Used to introduce serine residues with orthogonal protecting groups for site-specific modifications.
• Research & Development: A fundamental reagent in academic and industrial R&D for exploring new peptide structures and functions.
• Combinatorial Chemistry: Employed in libraries for high-throughput screening of novel peptide leads.

Basic Information

Product Name	Boc-Ser(Tbu)-Oh
CAS No.	13734-38-3
Molecular Formula	C12H23NO5
Molecular Weight	261.32 g/mol
Synonyms	N-α-(tert-Butoxycarbonyl)-O-tert-butyl-L-serine; Boc-L-serine tert-butyl ether; Boc-Ser(OtBu)-OH; (2S)-2-[(2-Methylpropan-2-yl)oxycarbonylamino]-3-[(2-methylpropan-2-yl)oxy]propanoic acid; tert-Butyl N-[(1S)-2-(tert-butoxy)-1-carboxyethyl]carbamate; Boc-Ser(TBU)-OH; L-Serine, N-[(1,1-dimethylethoxy)carbonyl]-, 1-(1,1-dimethylethyl) ester
EINECS	Contact for details

Quality Control

Our Boc-Ser(Tbu)-Oh is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and chiral integrity, to ensure it meets the high standards required for peptide synthesis. Certificates of Analysis (COA) with full specifications are provided for every shipment, ensuring traceability and consistency for your critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms
Assay (HPLC)	≥98.5%
Optical Rotation [α]	-15.0° to -18.0° (c=1 in AcOH)
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.