Description

n-(tert-Butoxycarbonyl)-L-Glutamine is a protected derivative of the amino acid L-glutamine, where the tert-butoxycarbonyl (Boc) group safeguards the amine functionality. This compound is a crucial building block in solid-phase peptide synthesis (SPPS), enabling the controlled elongation of peptide chains. It is primarily utilized by researchers and manufacturers in the pharmaceutical, biotechnology, and life sciences sectors for the development of novel peptides, APIs, and biochemical probes.

Application

• Solid-Phase Peptide Synthesis (SPPS): A fundamental Boc-protected amino acid for the sequential assembly of custom peptides.
• Pharmaceutical Intermediate: Used in the research and production of therapeutic peptides and active pharmaceutical ingredients (APIs).
• Bioconjugation: Serves as a reagent for introducing glutamine residues into biomolecules under controlled conditions.
• Biochemical Research: Employed in studies of protein structure, function, and enzyme-substrate interactions.
• Combinatorial Chemistry: A key component in libraries for drug discovery and high-throughput screening.
• Protecting Group Chemistry: Demonstrates the application of the Boc group for temporary amine protection in multi-step organic syntheses.

Basic Information

Product Name	n-(tert-Butoxycarbonyl)-L-Glutamine
CAS No.	13726-85-7
Molecular Formula	C₁₀H₁₈N₂O₅
Molecular Weight	246.26 g/mol
Synonyms	Boc-L-Glutamine; Boc-Gln-OH; N-Boc-L-glutamine; Nα-Boc-L-glutamine; (S)-2-((tert-Butoxycarbonyl)amino)-5-aminopentanoic acid; L-Glutamine, N-[(1,1-dimethylethoxy)carbonyl]-; N-(tert-Butoxycarbonyl)glutamine; Boc-Glutamine
EINECS	237-311-2

Quality Control

Our n-(tert-Butoxycarbonyl)-L-Glutamine is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis, and identity confirmation, to ensure it meets the high standards required for peptide synthesis and pharmaceutical research. Certificates of Analysis (COA) with detailed specifications are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Optical Rotation [α]²⁰D	-15.0° to -18.0° (c=1 in AcOH)
Loss on Drying	≤0.5%
Heavy Metals	≤10 ppm
Residue on Ignition	≤0.1%
Single Impurity (HPLC)	≤0.5%
Total Impurities (HPLC)	≤2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.