Description

n-tert-Butoxycarbonyl-L-Glutamic Acid γ-tert-Butyl Ester is a high-purity, protected amino acid derivative essential for advanced peptide synthesis. This compound matters because it provides orthogonal protection for the side-chain carboxylic acid group of glutamic acid, enabling precise, sequential coupling in complex peptide assembly. Pharmaceutical researchers and fine chemical manufacturers need it for the development of therapeutic peptides, peptidomimetics, and other bioactive molecules where controlled deprotection is critical.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key building block for introducing glutamic acid residues with protected side chains, preventing unwanted side reactions during chain elongation.
• Solution-Phase Peptide Synthesis: Used in the synthesis of complex peptides and small proteins where selective deprotection strategies are required.
• Pharmaceutical Intermediates: Serves as a critical intermediate in the research and production of peptide-based active pharmaceutical ingredients (APIs).
• Bioconjugation and Labeling: Facilitates the site-specific modification of peptides and proteins for diagnostic or therapeutic applications.
• Combinatorial Chemistry: Employed in libraries for drug discovery to explore structure-activity relationships of glutamic acid-containing compounds.
• Academic and R&D Laboratories: Used in fundamental research exploring peptide structure, function, and novel synthetic methodologies.

Basic Information

Product Name	n-tert-Butoxycarbonyl-L-Glutamic Acid γ-tert-Butyl Ester
CAS No.	13726-84-6
Molecular Formula	C₁₄H₂₅NO₆
Molecular Weight	303.35 g/mol
Synonyms	Boc-Glu(OtBu)-OH; Boc-L-Glu(OtBu)-OH; (2S)-2-[(2-Methylpropan-2-yl)oxycarbonylamino]pentanedioic acid 5-tert-butyl ester; N-Boc-L-glutamic acid 5-tert-butyl ester; N-(tert-Butoxycarbonyl)-L-glutamic acid 1-tert-butyl ester; L-Glutamic acid, N-(1,1-dimethylethoxy)carbonyl-, 5-(1,1-dimethylethyl) ester; Boc-Glu(OtBu); Glutamic acid derivative Boc-Glu(OtBu)-OH
EINECS	Contact for details

Quality Control

Our n-tert-Butoxycarbonyl-L-Glutamic Acid γ-tert-Butyl Ester is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for pharmaceutical research. Each lot undergoes comprehensive analytical testing, including HPLC for assay and chiral purity, and is supplied with a detailed Certificate of Analysis (COA). We adhere to cGMP principles where applicable to support our customers' regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); ensure the container is sealed after each use to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.5%
Optical Rotation [α]²⁰D	-15.0° to -17.0° (c=1 in AcOH)
Chiral Purity (HPLC)	≥99.0% (L-isomer)
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.