Description

n-[(Benzyloxy)Carbonyl]-L-Serine (Pentachlorophenyl) Ester is a specialized, high-purity amino acid derivative used as a key building block in peptide synthesis. This compound matters for its role as an activated ester, facilitating efficient and selective coupling reactions under mild conditions to construct complex peptide chains. It is primarily needed by research institutions and pharmaceutical companies engaged in the development of novel therapeutic peptides, peptidomimetics, and biochemical probes. Its consistent quality is critical for ensuring reproducible results in sensitive synthetic workflows.

Application

• Solid-Phase Peptide Synthesis (SPPS): As an activated amino acid derivative for the efficient incorporation of L-serine into peptide sequences.
• Solution-Phase Peptide Synthesis: Used in classical coupling methodologies for constructing peptides and peptide fragments.
• Bioconjugation: A reagent for introducing serine-containing linkers or functional handles onto biomolecules like proteins or antibodies.
• Medicinal Chemistry Research: A crucial intermediate in the synthesis of peptide-based drug candidates and bioactive compounds.
• Production of Custom Peptides: Employed by CROs and CDMOs for the reliable, gram-to-kilogram scale production of bespoke peptides for clients.
• Biochemical Tool Development: Used to create substrates, inhibitors, or probes for studying enzyme activity, particularly serine proteases or kinases.

Basic Information

Product Name	n-[(Benzyloxy)Carbonyl]-L-Serine (Pentachlorophenyl) Ester
CAS No.	13673-57-9
Molecular Formula	C17H14Cl5NO5
Molecular Weight	491.56 g/mol
Synonyms	Z-Ser-OH-Pcp; Z-L-Serine pentachlorophenyl ester; N-Carbobenzyloxy-L-serine pentachlorophenyl ester; Cbz-Ser-OPcp; (S)-2-(((Benzyloxy)carbonyl)amino)-3-hydroxypropanoic acid pentachlorophenyl ester; L-Serine, N-[(phenylmethoxy)carbonyl]-, pentachlorophenyl ester; NSC 334906; Pentafluorophenyl ester of Z-L-Serine (common misnomer, correct is pentachlorophenyl).
EINECS	Contact for details

Quality Control

Our n-[(Benzyloxy)Carbonyl]-L-Serine (Pentachlorophenyl) Ester is manufactured under strict quality systems to ensure high chemical purity and lot-to-lot consistency, suitable for demanding research and development applications. Each batch is characterized by advanced analytical techniques including HPLC, NMR, and mass spectrometry. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is light-sensitive (store away from light). For long-term storage, consider storage under inert atmosphere at temperatures below -15°C to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Specific Rotation [α]D20	Contact for details
Melting Point	Contact for details
Heavy Metals	< 20 ppm
Residual Solvents	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.