Description

Boc-Ser(Bzl)-Osu CAS NO 13650-73-2 is a protected amino acid derivative, specifically N-α-Boc-O-benzyl-L-serine N-hydroxysuccinimide ester, widely used as a key building block in solid-phase peptide synthesis (SPPS). Its primary value lies in enabling the controlled, racemization-free incorporation of serine into peptide chains while protecting the reactive side-chain hydroxyl group. This high-purity reagent is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and life sciences sectors developing therapeutic peptides, diagnostic agents, and complex biomolecules.

Application

• Solid-Phase Peptide Synthesis (SPPS): A critical reagent for the efficient, stepwise coupling of Boc-protected serine with benzyl side-chain protection to growing peptide chains.
• Therapeutic Peptide Production: Used in the research-scale and commercial synthesis of peptide-based pharmaceuticals, including hormones, antibiotics, and enzyme inhibitors.
• Bioconjugation and Labeling: Serves as an activated ester for coupling serine-containing sequences to other molecules, such as fluorescent dyes, polymers, or carrier proteins.
• Combinatorial Chemistry Libraries: Employed in the generation of diverse peptide libraries for drug discovery and high-throughput screening applications.
• Academic and Industrial Research: A fundamental tool for studying protein structure-function relationships, enzyme substrates, and receptor-ligand interactions.
• Custom Peptide Service Providers: A staple raw material for CROs and CDMOs offering bespoke peptide synthesis services to the global market.

Basic Information

Product Name	Boc-Ser(Bzl)-Osu
CAS No.	13650-73-2
Molecular Formula	C19H24N2O7
Molecular Weight	392.41 g/mol
Synonyms	N-α-Boc-O-benzyl-L-serine N-hydroxysuccinimide ester; Boc-Ser(Bzl)-OSu; tert-Butyloxycarbonyl-O-benzyl-L-serine N-succinimidyl ester; Boc-O-benzyl-L-serine active ester; Boc-L-Serine(Bzl)-OSu; N-(tert-Butoxycarbonyl)-O-benzyl-L-serine N-hydroxysuccinimide ester; (2,5-Dioxopyrrolidin-1-yl) (2S)-3-(benzyloxy)-2-[(tert-butoxycarbonyl)amino]propanoate
EINECS	Contact for details

Quality Control

Our Boc-Ser(Bzl)-Osu is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis to confirm enantiomeric integrity, and NMR/IR for structural confirmation. We provide Certificates of Analysis (COA) with detailed specifications for trace metals, residual solvents, and moisture content, ensuring compliance with the stringent requirements of pharmaceutical R&D and production.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as specified on the label. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and reactivity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Optical Rotation	[α]²⁰D: Specific range provided on COA
Water Content (KF)	≤0.5%
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.