Description

Z-Gly-Gly-Onp is a protected dipeptide derivative, specifically the p-nitrophenyl ester of Z-protected glycylglycine. This compound serves as a crucial building block in peptide synthesis, offering a reactive ester group for efficient amide bond formation under mild conditions. It is primarily utilized by researchers and manufacturers in the pharmaceutical and biotechnology sectors for the development of novel peptides and peptidomimetics.

Application

• Solid-Phase Peptide Synthesis (SPPS): As an activated ester for the controlled, sequential coupling of glycine residues.
• Solution-Phase Peptide Synthesis: For constructing specific dipeptide sequences in solution-based methodologies.
• Bioconjugation: Facilitating the attachment of glycylglycine motifs or other molecules to proteins, antibodies, or surfaces.
• Research & Development: A key intermediate in academic and industrial labs for exploring new peptide-based therapeutics and diagnostics.
• Production of Custom Peptides: Used by CROs and CDMOs for the contract manufacturing of complex peptide APIs.
• Enzyme Substrate Synthesis: Preparation of specialized substrates for protease and peptidase activity studies.

Basic Information

Product Name	Z-Gly-Gly-Onp
CAS No.	13574-81-7
Molecular Formula	C₁₈H₁₇N₃O₇
Molecular Weight	387.35 g/mol
Synonyms	N-Carbobenzoxy-glycyl-glycine p-nitrophenyl ester; Z-Gly-Gly-ONp; CBZ-Gly-Gly-ONp; N-(Benzyloxycarbonyl)glycylglycine 4-nitrophenyl ester; Glycine, N-[(phenylmethoxy)carbonyl]glycyl-, 4-nitrophenyl ester; Benzyl N-[2-[(4-nitrophenoxy)-oxoethyl]amino]-2-oxoethyl]carbamate; Z-Gly-Gly-OPhNO2; CBZ-Gly-Gly-OPhNO2
EINECS	Contact for details

Quality Control

Our Z-Gly-Gly-Onp is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the high standards required for synthetic applications. Certificates of Analysis (COA) with detailed specifications are provided to guarantee batch-to-batch consistency and traceability.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption, which can affect reactivity and stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.