Description

Boc-L-Glutamic Acid 5-Benzylester is a protected amino acid derivative essential for advanced peptide synthesis. This compound provides a crucial dual-protection strategy, safeguarding both the α-amino and the γ-carboxyl groups of glutamic acid, which is vital for constructing complex peptides with specific side-chain functionalities. It is a key building block for researchers and manufacturers in the pharmaceutical and biotechnology sectors, enabling the development of therapeutic peptides, peptidomimetics, and other bioactive molecules.

Application

• Solid-Phase Peptide Synthesis (SPPS): A fundamental reagent for the controlled, sequential assembly of peptide chains, particularly those requiring unprotected glutamic acid side chains.
• Pharmaceutical Intermediates: Serves as a critical precursor in the synthesis of active pharmaceutical ingredients (APIs) for various therapeutic areas.
• Bioconjugation and Labeling: Used to introduce glutamic acid residues with orthogonal protecting groups for site-specific modifications of proteins and peptides.
• Research & Development: An indispensable tool in academic and industrial R&D for exploring new peptide-based drugs and biochemical probes.
• Combinatorial Chemistry: Employed in libraries for high-throughput screening to discover novel lead compounds with biological activity.

Basic Information

Product Name	Boc-L-Glutamic Acid 5-Benzylester
CAS No.	13574-13-5
Molecular Formula	C₁₇H₂₃NO₆
Molecular Weight	337.37 g/mol
Synonyms	N-(tert-Butoxycarbonyl)-L-glutamic acid 5-benzyl ester; Boc-Glu(OBzl)-OH; (2S)-2-[(tert-Butoxycarbonyl)amino]pentanedioic acid 5-benzyl ester; Boc-L-Glu(OBzl); N-Boc-L-glutamic acid γ-benzyl ester; L-Glutamic acid, N-[(1,1-dimethylethoxy)carbonyl]-, 5-benzyl ester
EINECS	Contact for details

Quality Control

Our Boc-L-Glutamic Acid 5-Benzylester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and chiral integrity, to ensure it meets the high standards required for sensitive synthetic applications. Certificates of Analysis (COA) detailing purity, specific rotation, and impurity profiles are available for every lot to support your quality assurance and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Allow the container to reach room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥98.5%
Specific Rotation [α]²⁰D	-15.0° to -18.0° (c=1 in Acetic Acid)
Melting Point	78°C - 82°C
Heavy Metals	≤20 ppm
Residue on Ignition	≤0.1%
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.