Description

n-(p-Toluenesulfonyl)-L-Phenylalanine is a high-purity, protected amino acid derivative essential for advanced organic synthesis. This compound serves as a critical chiral building block, enabling the precise construction of complex molecules with defined stereochemistry. It is primarily utilized by research institutions and manufacturers in the pharmaceutical, biotechnology, and fine chemical industries for applications in peptide synthesis and medicinal chemistry.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of novel active pharmaceutical ingredients (APIs) and peptide-based therapeutics.
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis (SPPS) as a protected L-phenylalanine derivative, where the tosyl (Ts) group acts as a protective group for the amine functionality.
• Medicinal Chemistry Research: Employed in structure-activity relationship (SAR) studies and the synthesis of targeted compound libraries for drug discovery programs.
• Bioconjugation: Facilitates the site-specific modification of peptides and proteins for diagnostic and therapeutic applications.
• Fine Chemical Production: Serves as a precursor in the multi-step synthesis of specialized catalysts, ligands, and other high-value fine chemicals.
• Academic & Industrial R&D: A standard reagent in laboratory settings for methodological development in organic synthesis and asymmetric catalysis.

Basic Information

Product Name	n-(p-Toluenesulfonyl)-L-Phenylalanine
CAS No.	13505-32-3
Molecular Formula	C16H17NO4S
Molecular Weight	319.38 g/mol
Synonyms	N-Tosyl-L-phenylalanine; L-Phenylalanine, N-[(4-methylphenyl)sulfonyl]-; N-p-Toluenesulfonyl-L-phenylalanine; N-(4-Methylbenzenesulfonyl)-L-phenylalanine; Tosyl-L-phenylalanine; (2S)-2-[(4-Methylphenyl)sulfonylamino]-3-phenylpropanoic acid; N-Ts-L-Phe-OH; NSC 3349
EINECS	Contact for details

Quality Control

Our n-(p-Toluenesulfonyl)-L-Phenylalanine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and chiral integrity, to ensure it meets the high standards required for research and synthesis. Certificates of Analysis (COA) with detailed specifications are provided for every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). This product is moisture-sensitive; keep the container tightly sealed in a dry environment.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.