Description

H-Tyr(Tos)-Oh.Acetate CAS NO 13504-89-7 is a protected tyrosine derivative, specifically O-tosyl-L-tyrosine acetate salt, widely used as a critical building block in peptide synthesis. This compound is essential for researchers and manufacturers requiring precise control over tyrosine side-chain reactivity during solid-phase or solution-phase peptide assembly. It is primarily utilized by the pharmaceutical, biotechnology, and academic research sectors for developing novel therapeutic peptides, diagnostic agents, and biochemical tools.

Application

• Peptide Synthesis Intermediate: A key protected amino acid for the controlled incorporation of tyrosine into peptide chains, preventing unwanted side reactions.
• Pharmaceutical Research & Development: Used in the discovery and production of peptide-based drugs, including hormone analogs, enzyme inhibitors, and targeted therapeutics.
• Bioconjugation & Labeling: Serves as a precursor for creating tyrosine-containing linkers used in antibody-drug conjugates (ADCs) or fluorescent probes.
• Biochemical Tool Development: Employed in synthesizing substrates for kinase and phosphatase activity assays, leveraging the phosphorylatable phenol group.
• Combinatorial Chemistry Libraries: A valuable component for generating diverse peptide libraries for high-throughput screening in drug discovery.
• Academic & Institutional Research: Used in university and institutional labs for fundamental studies in peptide chemistry, protein engineering, and medicinal chemistry.

Basic Information

Product Name	H-Tyr(Tos)-Oh.Acetate
CAS No.	13504-89-7
Molecular Formula	C18H21NO6S
Molecular Weight	379.43 g/mol
Synonyms	O-Tosyl-L-tyrosine acetate salt; L-Tyrosine, O-[(4-methylphenyl)sulfonyl]-, acetate (salt); H-Tyr(Tos)-OH · AcOH; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-O-(4-methylbenzenesulfonyl)-L-tyrosine; Fmoc-Tyr(Tos)-OH (related protected form); (2S)-2-Amino-3-[4-[(4-methylphenyl)sulfonyl]oxy]phenyl]propanoic acid acetate; Acetyl O-tosyltyrosine; Protected L-Tyrosine derivative.
EINECS	Contact for details

Quality Control

Our H-Tyr(Tos)-Oh.Acetate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, chiral analysis for enantiomeric excess, and NMR for structural confirmation, to ensure it meets the high standards required for peptide synthesis. Certificates of Analysis (COA) with detailed specifications are provided to guarantee traceability, consistency, and compliance with research and cGMP guidelines where applicable.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Optical Rotation	[α]²⁰D: Contact for details
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.