Description

Z-cis-Hyp-Oh is a specific stereoisomer of hydroxyproline, a non-standard amino acid derivative with a cis-configuration about the pyrrolidine ring. This compound is of significant value in advanced peptide synthesis and biochemical research, where precise stereochemistry is critical for mimicking natural protein structures and studying biological activity. It serves as a key chiral building block for researchers and manufacturers in the pharmaceutical, biotechnology, and advanced materials sectors.

Application

• Peptide Synthesis: As a chiral synthon for constructing collagen-like peptides and other complex biomolecules requiring the cis-4-hydroxyproline configuration.
• Pharmaceutical Intermediates: Used in the research and development of novel therapeutic agents, including enzyme inhibitors and receptor modulators.
• Biochemical Research: A critical standard and reagent for studying collagen stability, protein folding, and enzyme-substrate interactions.
• Cosmetic & Dermatological Actives: Incorporated into advanced formulations aimed at skin repair and anti-aging, leveraging its role in collagen structure.
• Academic & Industrial R&D: Serves as a fundamental tool in organic chemistry and medicinal chemistry laboratories for stereochemical studies.

Basic Information

Product Name	Z-cis-Hyp-Oh
CAS No.	13504-86-4
Molecular Formula	C₁₃H₁₅NO₅
Molecular Weight	265.26 g/mol
Synonyms	N-Carbobenzoxy-cis-4-hydroxy-L-proline; Z-cis-4-Hydroxy-L-proline; N-[(Benzyloxy)carbonyl]-cis-4-hydroxy-L-proline; (2S,4R)-1-[(Benzyloxy)carbonyl]-4-hydroxypyrrolidine-2-carboxylic acid; cis-4-Hydroxy-L-proline N-benzyloxycarbonyl derivative; Z-cis-Hyp; Z-cis-4-Hyp-OH; N-Cbz-cis-4-hydroxy-L-proline
EINECS	Contact for details

Quality Control

Our Z-cis-Hyp-Oh is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for research and synthesis. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee identity, purity, and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The product is hygroscopic (moisture-sensitive); ensure the container is sealed after each use to prevent moisture uptake.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% (cis-isomer)
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.