Description

L-Proline, 4-Ethoxy-, trans- (9Ci) is a chemically modified derivative of the natural amino acid L-proline, featuring an ethoxy substituent at the 4-position. This structural modification imparts unique steric and electronic properties, making it a valuable chiral building block and intermediate in advanced organic synthesis. It is primarily sought after by research institutions and pharmaceutical companies engaged in the development of novel bioactive compounds, peptidomimetics, and asymmetric catalysts. The compound is supplied with the CAS registry number 13500-55-5.

Application

• Pharmaceutical Intermediate: Serves as a key chiral synthon in the research and development of new drug candidates, particularly for protease inhibitors and other peptide-based therapeutics.
• Asymmetric Catalysis: Used as a precursor or ligand in the design of organocatalysts for enantioselective synthesis, crucial for producing single-isomer active pharmaceutical ingredients (APIs).
• Peptidomimetic Research: Incorporated into synthetic peptide analogs to study structure-activity relationships (SAR) and enhance metabolic stability or bioavailability.
• Biochemical Research: Employed as a specialized substrate or inhibitor in enzymatic studies to probe the function of proline-specific enzymes.
• Fine Chemical Synthesis: Acts as a building block for the synthesis of complex natural products, flavors, and fragrances requiring high stereochemical purity.

Basic Information

Product Name	L-Proline, 4-Ethoxy-, trans- (9Ci)
CAS No.	13500-55-5
Molecular Formula	C7H13NO3
Molecular Weight	159.18 g/mol
Synonyms	(2S,4R)-4-Ethoxyproline; trans-4-Ethoxy-L-proline; L-4-Ethoxyproline; 4-Ethoxy-L-proline; (2S,4R)-4-Ethoxypyrrolidine-2-carboxylic acid; 4-Ethoxy-(S)-proline; (S)-4-Ethoxyproline; 13500-55-5
EINECS	Contact for details

Quality Control

Our L-Proline, 4-Ethoxy-, trans- (9Ci) is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification and impurity profiling, to ensure it meets the high standards required for research and development applications. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming identity, purity, and specific physical characteristics.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (typically 15-25°C). The product may be hygroscopic; keep the container tightly sealed to minimize exposure to moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.