Description

L-Ala-Otbu.Hcl is a protected amino acid derivative, specifically the hydrochloride salt of L-alanine tert-butyl ester. This compound serves as a crucial building block in organic synthesis, particularly for the preparation of peptides and complex molecules where selective deprotection is required. It is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and fine chemical sectors engaged in drug discovery and process development.

Application

• Peptide Synthesis: A key intermediate for the solid-phase and solution-phase synthesis of peptides and peptidomimetics.
• Pharmaceutical Intermediates: Used in the research and production of active pharmaceutical ingredients (APIs) and prodrugs.
• Bioconjugation: Acts as a linker or spacer molecule in the modification of proteins, antibodies, and other biomolecules.
• Chemical Biology Research: Employed in the study of enzyme mechanisms and the development of biochemical probes.
• Fine Chemical Production: Serves as a chiral synthon for the asymmetric synthesis of complex organic compounds.
• Protecting Group Strategy: The tert-butyl ester group provides orthogonal protection that can be cleaved under mild acidic conditions without affecting other sensitive functionalities.

Basic Information

Product Name	L-Ala-Otbu.Hcl
CAS No.	13404-22-3
Molecular Formula	C7H16ClNO2
Molecular Weight	181.66 g/mol
Synonyms	L-Alanine tert-butyl ester hydrochloride; H-Ala-OtBu·HCl; (S)-2-Aminopropionic acid tert-butyl ester hydrochloride; tert-Butyl L-alaninate hydrochloride; Alanine, tert-butyl ester, hydrochloride, L-; L-2-Aminopropionic acid tert-butyl ester hydrochloride; Boc-Ala-OH (Note: This is a common confusion; Boc-Ala-OH is a different protecting group); ATBU.HCl
EINECS	Contact for details

Quality Control

Our L-Ala-Otbu.Hcl is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure high purity, identity, and consistency, meeting the stringent requirements for research and cGMP-grade manufacturing. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting key parameters such as assay, chiral purity, and impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% (L-Isomer)
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Solubility	Freely soluble in water, methanol, DMF

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.