Description

n-Formyl-L-Phenylalanine is a protected derivative of the essential amino acid L-phenylalanine, where the amino group is blocked by a formyl moiety. This modification is crucial in peptide synthesis, as it prevents unwanted side reactions and allows for the selective deprotection and elongation of peptide chains. It serves as a key chiral building block and intermediate for researchers and manufacturers in the pharmaceutical, biotechnology, and fine chemical sectors, particularly in the development of novel therapeutic peptides and active pharmaceutical ingredients (APIs).

Application

• Solid-Phase Peptide Synthesis (SPPS): A fundamental protected amino acid for the Fmoc/t-Bu strategy, enabling the controlled assembly of complex peptide sequences.
• Pharmaceutical Intermediate: Critical starting material or intermediate in the synthesis of peptide-based drugs, hormone analogs, and other bioactive compounds.
• Biochemical Research: Used in enzymatic studies, as a substrate analog, and in the investigation of metabolic pathways involving phenylalanine.
• Chiral Pool Synthesis: Provides a source of enantiomerically pure L-configuration for the asymmetric synthesis of non-peptide molecules.
• Protecting Group Chemistry: Serves as a model compound for studying formyl group introduction and removal under various conditions.
• Fine Chemical Production: Intermediate in the manufacture of specialty chemicals, flavors, and fragrances requiring specific chiral centers.

Basic Information

Product Name	n-Formyl-L-Phenylalanine
CAS No.	13200-85-6
Molecular Formula	C10H11NO3
Molecular Weight	193.20 g/mol
Synonyms	N-Formyl-L-phenylalanine; (S)-2-Formamido-3-phenylpropanoic acid; L-Phenylalanine, N-formyl-; F-Phe-OH; For-Phe-OH; N-Formylphenylalanine; Formylphenylalanine; NSC 3349
EINECS	Contact for details

Quality Control

Our n-Formyl-L-Phenylalanine is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including chiral purity verification, to ensure it meets the high standards required for research and cGMP manufacturing. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming specifications for identity, assay, optical rotation, and impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Optical Rotation [α]	-20.0° to -25.0° (c=1 in AcOH)
Chiral Purity (HPLC)	≥99.0% (L-isomer)
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.