Description

H-D-Asp(Obzl)-Oh CAS NO 13188-89-1 is a protected aspartic acid derivative, specifically the benzyl ester of H-Asp-OH, serving as a crucial chiral building block in advanced organic synthesis. Its primary value lies in enabling the controlled introduction of the aspartic acid moiety into peptide chains and other complex molecules while preventing unwanted side reactions at the carboxylic acid group. This high-purity intermediate is essential for research and production in pharmaceutical development, particularly for creating novel peptide-based therapeutics and active pharmaceutical ingredients (APIs).

Application

• Peptide Synthesis: A key protected amino acid derivative for solid-phase and solution-phase synthesis of complex peptides and proteins.
• Pharmaceutical Intermediates: Serves as a critical chiral building block in the manufacture of peptide-based drugs and active pharmaceutical ingredients (APIs).
• Bioconjugation & Linker Chemistry: Used in the development of antibody-drug conjugates (ADCs) and other bioconjugates where a protected acidic function is required.
• Chemical Biology Research: Employed in the synthesis of modified peptides and peptidomimetics for structure-activity relationship (SAR) studies.
• Catalyst & Ligand Preparation: Acts as a precursor for synthesizing specialized ligands and catalysts used in asymmetric synthesis.
• Fine Chemical Production: An intermediate in the multi-step synthesis of various high-value, specialized fine chemicals and agrochemicals.

Basic Information

Product Name	H-D-Asp(Obzl)-Oh
CAS No.	13188-89-1
Molecular Formula	C11H13NO4
Molecular Weight	223.23 g/mol
Synonyms	H-D-Aspartic acid β-benzyl ester; (R)-2-Amino-3-(benzyloxy)-3-oxopropanoic acid; D-Aspartic acid β-benzyl ester; D-Asp(OBzl)-OH; Benzyl D-aspartate; (R)-2-Amino-3-benzyloxy-3-oxopropanoic acid; (R)-3-(Benzyloxy)-2-((tert-butoxycarbonyl)amino)-3-oxopropanoic acid (related Boc-protected form); D-Aspartic acid 4-benzyl ester
EINECS	Contact for details

Quality Control

Our H-D-Asp(Obzl)-Oh is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC for chiral purity and assay, to meet the stringent requirements of pharmaceutical R&D and production. Certificates of Analysis (COA) detailing all specifications are provided with every shipment to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider storing under an inert atmosphere such as argon or nitrogen to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.5%
Chiral Purity (HPLC)	≥99.0% (D-isomer)
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm
Single Impurity (HPLC)	≤0.5%
Total Impurities (HPLC)	≤1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.