Description

Z-D-Gln-Oh is a protected derivative of the amino acid glutamine, where the amine group is protected by a benzyloxycarbonyl (Z) group and the side chain carboxamide is presented as a free carboxylic acid (OH). This specific configuration makes it a crucial chiral building block in the synthesis of complex peptides and peptidomimetics. It is primarily utilized by research institutions and pharmaceutical companies engaged in advanced peptide chemistry and drug discovery. The compound offers high purity and stereochemical integrity, which are essential for ensuring the biological activity and consistency of the final synthesized products.

Application

• Pharmaceutical Intermediates: Serves as a key chiral synthon in the solid-phase and solution-phase synthesis of therapeutic peptides.
• Peptide Research: Used in academic and industrial R&D for constructing peptide libraries and studying structure-activity relationships (SAR).
• API Development: Employed in the development and scale-up of Active Pharmaceutical Ingredients (APIs) that contain glutamine residues with specific protection schemes.
• Bioconjugation: Acts as a precursor for creating linkers or modified amino acids used in antibody-drug conjugates (ADCs) and other bioconjugates.
• Biochemical Tools: Utilized in the synthesis of enzyme substrates, inhibitors, and probes for biochemical assays.

Basic Information

Product Name	Z-D-Gln-Oh
CAS No.	13139-52-1
Molecular Formula	C₁₃H₁₆N₂O₅
Molecular Weight	280.28 g/mol
Synonyms	N-Benzyloxycarbonyl-D-glutamine; Z-D-Glutamine; (R)-2-((((Benzyloxy)carbonyl)amino)-5-amino-5-oxopentanoic acid; D-Glutamine, N-[(benzyloxy)carbonyl]-; CBZ-D-Glutamine; N-Cbz-D-glutamine; Nα-Carbobenzoxy-D-glutamine; Z-D-Glutamine-OH
EINECS	Contact for details

Quality Control

Our Z-D-Gln-Oh is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity analysis, to ensure it meets the high standards required for pharmaceutical research and development. Certificates of Analysis (COA) detailing purity, identity, and specific impurity profiles are provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed after each use to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% (D-isomer)
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.