Description

Boc-L-Leucine CAS NO 13139-15-6 is a vital N-α-protected derivative of the essential amino acid L-Leucine, featuring the tert-butoxycarbonyl (Boc) protecting group. This compound is fundamental in solid-phase peptide synthesis (SPPS) and other organic synthesis workflows, where it provides critical orthogonality and stability under various reaction conditions. It is an indispensable building block for researchers and manufacturers in the pharmaceutical, biotechnology, and fine chemical industries developing peptide-based therapeutics, diagnostic agents, and novel biomaterials.

Application

• Peptide Synthesis: A key protected amino acid monomer for the automated synthesis of complex peptides and proteins using Fmoc/t-Bu or Boc/Bzl strategies.
• Pharmaceutical Intermediates: Serves as a crucial intermediate in the production of active pharmaceutical ingredients (APIs) for various therapeutic areas.
• Bioconjugation & Linker Chemistry: Used to introduce the leucine moiety into molecules for drug delivery systems, antibody-drug conjugates (ADCs), and probe labeling.
• Biochemical Research: Employed in studying enzyme-substrate interactions, protein folding, and metabolic pathways as a standardized reagent.
• Fine Chemical Synthesis: Acts as a chiral building block for the asymmetric synthesis of non-peptidic compounds with high enantiomeric purity.
• Cosmetic Peptides: A raw material in the synthesis of bioactive peptides used in advanced skincare and cosmetic formulations.

Basic Information

Product Name	Boc-L-Leucine
CAS No.	13139-15-6
Molecular Formula	C11H21NO4
Molecular Weight	231.29 g/mol
Synonyms	(S)-2-((tert-Butoxycarbonyl)amino)-4-methylpentanoic acid; N-(tert-Butoxycarbonyl)-L-leucine; N-Boc-L-leucine; Boc-Leu-OH; BOC-L-LEU; (S)-2-(tert-Butoxycarbonylamino)-4-methylvaleric acid; N-α-Boc-L-leucine; tert-Butyloxycarbonyl-L-leucine
EINECS	236-077-5

Quality Control

Our Boc-L-Leucine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, chiral analysis for enantiomeric excess, and comprehensive identification tests. We provide full traceability and Certificates of Analysis (COA) are available for every shipment, ensuring compliance with your research and cGMP production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). The product is hygroscopic (moisture-sensitive); keep the container tightly sealed in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.5%
Optical Rotation [α]20/D	-25.0° to -27.0° (c=1 in AcOH)
Melting Point	84°C - 88°C
Heavy Metals (as Pb)	≤20 ppm
Residue on Ignition	≤0.1%
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.