Description

Z-Phe-Val-Oh CAS NO 13123-00-7 is a protected dipeptide building block, specifically Z-Phenylalanyl-Valine, widely utilized in solid-phase peptide synthesis (SPPS). This compound is critical for researchers and manufacturers requiring high-purity intermediates to construct complex peptide sequences with precise stereochemistry. It serves as an essential raw material for pharmaceutical R&D, particularly in the development of therapeutic peptides, and is also valuable in biochemical research for studying enzyme-substrate interactions and protein folding.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel therapeutic peptide candidates for metabolic, oncological, and neurological disorders.
• Solid-Phase Peptide Synthesis (SPPS): Used extensively in Fmoc/t-Bu and Boc/Bzl strategies for the sequential assembly of custom peptide chains.
• Biochemical Research: Employed as a substrate or inhibitor in enzymatic studies and for probing protease specificity and kinetics.
• Peptide Library Construction: Facilitates the generation of diverse peptide libraries for high-throughput screening in drug discovery.
• API Development: Serves as a critical intermediate in the scalable production of Active Pharmaceutical Ingredients (APIs) for peptide-based drugs.
• Academic Research: Used in university and institutional labs for teaching advanced peptide chemistry and conducting fundamental life science research.

Basic Information

Product Name	Z-Phe-Val-Oh
CAS No.	13123-00-7
Molecular Formula	C22H26N2O5
Molecular Weight	398.46 g/mol
Synonyms	N-Carbobenzoxy-L-phenylalanyl-L-valine; Z-L-Phenylalanyl-L-valine; Z-Phe-Val-OH; Z-Phenylalanyl-Valine; CBZ-Phe-Val-OH; Nα-CBZ-L-Phenylalanyl-L-valine; Benzyloxycarbonyl-L-phenylalanyl-L-valine; N-CBZ-L-Phenylalanyl-L-valine
EINECS	Contact for details

Quality Control

Our Z-Phe-Val-Oh is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, suitable for demanding research and GMP-grade synthesis. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing purity, chiral integrity, and impurity profiles. We adhere to relevant industry standards and can provide material tailored to specific pharmacopeial requirements (e.g., USP, EP) upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed after each use to prevent exposure to atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Optical Rotation	-15.0° to -18.0° (c=1 in DMF)
Chiral Purity (HPLC)	≥99.0% (L-L isomer)
Water Content (KF)	≤0.5%
Heavy Metals	≤10 ppm
Residual Solvents (GC)	Complies with ICH Q3C

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.