Description

H-D-Leu-Otbu Hcl is a protected amino acid derivative, specifically the hydrochloride salt of H-D-Leucine tert-butyl ester. This compound is a crucial chiral building block in the synthesis of complex peptides and active pharmaceutical ingredients (APIs), offering high stereochemical purity for demanding applications. It is primarily utilized by research institutions and manufacturers in the pharmaceutical, biotechnology, and fine chemical sectors for developing novel therapeutic agents and advanced biomolecules.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the solid-phase and solution-phase synthesis of peptide-based drugs and APIs.
• Peptide Research: Used in academic and industrial R&D for constructing custom peptides with specific sequences and properties.
• Protease Inhibitor Development: Serves as a precursor in the creation of enzyme inhibitors targeting proteases.
• Bioconjugation: Employed in the modification of proteins and other biomolecules for diagnostic or therapeutic purposes.
• Combinatorial Chemistry: A valuable component in libraries for high-throughput screening to discover new bioactive compounds.
• Agrochemical Synthesis: Can be used in the development of chiral, biologically active compounds for crop protection.

Basic Information

Product Name	H-D-Leu-Otbu Hcl
CAS No.	13081-32-8
Molecular Formula	C₁₁H₂₄ClNO₂
Molecular Weight	237.77 g/mol
Synonyms	H-D-Leucine tert-butyl ester hydrochloride; (R)-2-((tert-Butoxycarbonyl)amino)-4-methylpentanoic acid hydrochloride; D-Leucine, 1,1-dimethylethyl ester, hydrochloride; Boc-D-Leu-OtBu·HCl; tert-Butyl (R)-2-amino-4-methylpentanoate hydrochloride; N-Boc-D-leucine tert-butyl ester hydrochloride; D-Leucine tert-butyl ester HCl; Boc-D-Leu-OtBu hydrochloride
EINECS	Contact for details

Quality Control

Our H-D-Leu-Otbu Hcl is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis for enantiomeric excess, and identity confirmation via IR and NMR spectroscopy. We provide full traceability and Certificates of Analysis (COA) are available for all shipments, ensuring compliance with your research or cGMP-grade requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and must be kept under dry, inert conditions to maintain stability and purity. For long-term storage, consider desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.