Description

[3-(n-Methylacetylamino)-2,4,6-Triiodophenoxy]Acetic Acid is a specialized iodinated organic compound that serves as a crucial intermediate in the synthesis of X-ray contrast media. This high-purity intermediate is essential for ensuring the safety and efficacy of final diagnostic formulations. It is primarily required by pharmaceutical manufacturers and advanced chemical synthesis facilities developing non-ionic, low-osmolar contrast agents for enhanced medical imaging procedures.

Application

• Key Intermediate for X-ray Contrast Media: Primary building block in the synthesis of iopamidol, iohexol, and other non-ionic contrast agents.
• Pharmaceutical Active Pharmaceutical Ingredient (API) Synthesis: Used in controlled chemical processes to create the core structure of diagnostic agents.
• Research & Development: Serves as a critical reagent in the development of new iodinated contrast molecules with improved safety profiles.
• Fine Chemical Manufacturing: Employed in multi-step organic synthesis requiring high regioselectivity and purity.
• Radiology Diagnostic Agent Production: Integral to manufacturing processes for agents used in computed tomography (CT), angiography, and myelography.

Basic Information

Product Name	[3-(n-Methylacetylamino)-2,4,6-Triiodophenoxy]Acetic Acid
CAS No.	13080-24-5
Molecular Formula	C11H11I3NO4
Molecular Weight	649.92 g/mol
Synonyms	5-Acetamido-2,4,6-triiodo-N-methylisophthalamic acid; Acetic acid, [3-[(acetyl methylamino)-2,4,6-triiodophenoxy]-; 5-(N-Methylacetamido)-2,4,6-triiodoisophthalamic acid; Iopamidol intermediate; Iohexol intermediate; N-Methyl-5-acetamido-2,4,6-triiodoisophthalamic acid; WIN 39424; Compound 39424
EINECS	Contact for details

Quality Control

Our [3-(n-Methylacetylamino)-2,4,6-Triiodophenoxy]Acetic Acid is manufactured under strict quality systems suitable for pharmaceutical intermediate applications. Quality is assured through rigorous in-process controls and final testing against established specifications, which may include HPLC purity, residual solvent analysis, and heavy metal limits. A comprehensive Certificate of Analysis (COA) is provided with each batch, and we can support compliance with cGMP, ICH Q7, and other relevant regulatory guidelines upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at controlled room temperature (15-25°C). This material is light-sensitive (store away from light) and easily oxidized (store under inert atmosphere). Keep container tightly sealed under an inert gas blanket (e.g., nitrogen or argon) to minimize oxidation and moisture uptake. Store away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Iodine Content	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.