Description

[3-(n-Ethylacetylamino)-2,4,6-Triiodophenoxy]Acetic Acid is a specialized iodinated organic compound with a high molecular weight, primarily valued for its role as a key intermediate in the synthesis of X-ray contrast media. This compound matters because it provides the essential triiodinated aromatic core required for achieving high radiopacity in diagnostic imaging agents. Pharmaceutical manufacturers and advanced fine chemical suppliers need this high-purity intermediate to develop non-ionic, low-osmolar contrast agents for enhanced patient safety and diagnostic clarity.

Application

• Primary Intermediate for X-ray Contrast Media: Critical building block in the synthesis of iopamidol, iohexol, and other non-ionic contrast agents.
• Pharmaceutical Research & Development (R&D): Used in developing new generations of diagnostic imaging compounds with improved safety profiles.
• Fine Chemical Synthesis: Serves as a precursor for other complex iodinated aromatic molecules used in various specialty applications.
• Contrast Agent Manufacturing: Integral to the commercial-scale production batches of finished pharmaceutical formulations.
• Radiology & Diagnostic Imaging: Ultimately enables clear visualization of blood vessels, organs, and tissues in computed tomography (CT) and angiography.

Basic Information

Product Name	[3-(n-Ethylacetylamino)-2,4,6-Triiodophenoxy]Acetic Acid
CAS No.	13080-22-3
Molecular Formula	C12H13I3NO4
Molecular Weight	641.95 g/mol
Synonyms	5-Acetamido-2,4,6-triiodo-N-ethylisophthalamic acid; AEIT; Acetic acid, [3-[(ethylamino)carbonyl]-2,4,6-triiodo-5-(acetylamino)phenoxy]-; 3-(N-Ethylacetamido)-2,4,6-triiodo-5-carboxymethoxyaniline; Iopamidol Intermediate; Iohexol Intermediate; 5-Acetamido-2,4,6-triiodo-N-ethylisophthalamic acid; Contrast Media Intermediate AEIT
EINECS	Contact for details

Quality Control

Our [3-(n-Ethylacetylamino)-2,4,6-Triiodophenoxy]Acetic Acid is manufactured under strict quality systems suitable for pharmaceutical intermediates. Each batch undergoes rigorous analytical testing, including HPLC for purity and related substances, to ensure compliance with stringent internal specifications. Certificates of Analysis (COA) detailing identity, assay, and impurity profiles are provided to support your regulatory and manufacturing requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). This product is light-sensitive and should be stored away from direct light. It is also easily oxidized; for long-term storage, consider an inert atmosphere (e.g., nitrogen or argon blanket). Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Individual Unknown Impurity	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Heavy Metals	≤ 20 ppm
Loss on Drying	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.