Description

Z-His-Phe-Phe-Oet is a synthetic tripeptide derivative featuring a C-terminal ethyl ester and an N-terminal benzyloxycarbonyl (Z) protecting group. This compound serves as a crucial building block and research intermediate in peptide synthesis and medicinal chemistry. It is primarily utilized by researchers and manufacturers in the pharmaceutical and biotechnology sectors for developing novel therapeutic agents and studying enzyme-substrate interactions.

Application

• Pharmaceutical Intermediate: A key precursor in the solid-phase and solution-phase synthesis of more complex bioactive peptides.
• Protease/Enzyme Substrate: Used in biochemical research to study the specificity and inhibition of proteolytic enzymes like chymotrypsin or cathepsins.
• Medicinal Chemistry Research: Serves as a scaffold for structure-activity relationship (SAR) studies to optimize peptide-based drug candidates.
• Bioconjugation: The reactive functional groups allow for conjugation to carriers or labels in diagnostic probe development.
• Reference Standard: Employed as a high-purity analytical standard in quality control laboratories for method development and validation.

Basic Information

Product Name	Z-His-Phe-Phe-Oet
CAS No.	13053-61-7
Molecular Formula	C33H38N6O6
Molecular Weight	614.69 g/mol
Synonyms	Z-His-Phe-Phe-OEt; Nα-Benzyloxycarbonyl-L-histidyl-L-phenylalanyl-L-phenylalanine ethyl ester; CBZ-His-Phe-Phe-OEt; Benzyloxycarbonyl-L-histidyl-L-phenylalanyl-L-phenylalanine ethyl ester; Z-L-His-L-Phe-L-Phe-OEt; N-CBZ-L-histidyl-L-phenylalanyl-L-phenylalanine ethyl ester; (S)-Ethyl 2-((S)-2-((S)-3-(1-(benzyloxycarbonyl)-1H-imidazol-4-yl)propanamido)-3-phenylpropanamido)-3-phenylpropanoate
EINECS	Contact for details

Quality Control

Our Z-His-Phe-Phe-Oet is produced under controlled conditions to ensure high chemical purity and batch-to-batch consistency. Quality is verified through a comprehensive suite of analytical techniques including HPLC, NMR, and mass spectrometry. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to support your research and development requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container should be kept in a desiccated environment to prevent moisture uptake, which can affect stability and handling properties.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms to reference spectrum
Purity (HPLC)	≥ 97.0%
Assay	≥ 95.0% (on anhydrous basis)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.