Description

3-[[4-[[3-Carboxy-2,4,6-Triiodo-5-(Methylcarbamoyl)Phenyl]Carbamoyl]Benzoyl]Amino]-2,4,6-Triiodo-5-(Methylcarbamoyl)Benzoic Acid is a high-purity, iodinated organic compound primarily used as a key intermediate in the synthesis of advanced X-ray contrast media. Its complex molecular structure, featuring multiple iodine atoms, is critical for imparting the necessary radiopacity required in diagnostic imaging agents. This compound is essential for pharmaceutical manufacturers and research institutions developing next-generation non-ionic, low-osmolar contrast agents for enhanced patient safety and diagnostic clarity.

Application

• Pharmaceutical Intermediate: Primary building block for the synthesis of iodinated X-ray contrast media, such as Iopamidol, Ioversol, and Ioxaglate derivatives.
• Diagnostic Imaging Research: Used in R&D for developing novel non-ionic contrast agents with improved safety profiles and pharmacokinetics.
• Contrast Agent Production: A critical precursor in the multi-step synthesis of final drug substances for computed tomography (CT) and angiography.
• Chemical Reference Standard: Serves as a high-purity standard for quality control and analytical method development in pharmaceutical manufacturing.
• Radiopharmaceutical Synthesis: Potential intermediate in the research of targeted imaging agents, leveraging its iodine content.

Basic Information

Product Name	3-[[4-[[3-Carboxy-2,4,6-Triiodo-5-(Methylcarbamoyl)Phenyl]Carbamoyl]Benzoyl]Amino]-2,4,6-Triiodo-5-(Methylcarbamoyl)Benzoic Acid
CAS No.	13013-78-0
Molecular Formula	C25H15I6N4O8
Molecular Weight	1303.73 g/mol
Synonyms	5-[3-Carboxy-2,4,6-triiodo-5-(methylcarbamoyl)benzamido]-2,4,6-triiodoisophthalamic acid; Iopamidol Impurity; Iopamidol Intermediate; Ioversol Related Compound; 3,3',5,5'-Tetraiodo-4,4'-bis[(N-methylcarbamoyl)]-2,2',6,6'-tetracarboxybiphenyl; AD-01; Ioxaglate Acid Intermediate; Non-Ionic Contrast Media Intermediate
EINECS	Contact for details

Quality Control

Our 3-[[4-[[3-Carboxy-2,4,6-Triiodo-5-(Methylcarbamoyl)Phenyl]Carbamoyl]Benzoyl]Amino]-2,4,6-Triiodo-5-(Methylcarbamoyl)Benzoic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the stringent requirements for pharmaceutical intermediate applications. Certificates of Analysis (COA) detailing all specifications are provided with every shipment to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed and away from direct light exposure to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Heavy Metals	≤ 20 ppm
Loss on Drying	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.