Description

Substance P CAS NO 12769-48-1 is a potent neuropeptide belonging to the tachykinin family, widely recognized for its role as a neurotransmitter and neuromodulator. It is critical for research in neuroscience, immunology, and pain management due to its involvement in signal transduction and inflammatory responses. This high-purity peptide is essential for pharmaceutical R&D, academic research, and diagnostic applications requiring precise biological activity.

Application

• Neuroscience Research: Used to study pain pathways, neurogenic inflammation, and the role of the neurokinin-1 (NK1) receptor.
• Immunology Studies: Investigated for its effects on mast cell degranulation, cytokine release, and immune cell communication.
• Drug Discovery & Development: Serves as a reference standard and key reagent in screening for NK1 receptor antagonists and novel analgesics.
• Cell Biology & Signal Transduction: Employed in assays to understand G-protein coupled receptor (GPCR) activation and intracellular calcium mobilization.
• Diagnostic Development: Utilized in the development of immunoassays and as a calibrator for quantitative analysis in biological samples.

Basic Information

Product Name	Substance P
CAS No.	12769-48-1
Molecular Formula	C63H98N18O13S
Molecular Weight	1347.63 g/mol
Synonyms	Substance P (human, bovine, canine, guinea pig, mouse, pig, rabbit, rat); Neurokinin P; SP; Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2; Tachykinin, precursor 1; TAC1; NK-1 Receptor Agonist
EINECS	Contact for details

Quality Control

Our Substance P is manufactured under strict quality systems to ensure high purity and biological activity. Each batch is characterized using advanced analytical techniques including HPLC and mass spectrometry. Certificates of Analysis (COA) detailing purity, peptide content, and endotoxin levels are provided to support your research and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store desiccated at -20°C or below for long-term stability. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80%
Water Content (KF)	≤ 5.0%
Acetate Content (HPLC)	≤ 10.0%
Endotoxin Level	< 10 EU/mg

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.