Description

Angiotensin III, Human is a bioactive heptapeptide fragment of the renin-angiotensin system (RAS) with the CAS Registry Number 12687-51-3. This compound is a critical research tool for investigating cardiovascular physiology, renal function, and the mechanisms of blood pressure regulation. It is essential for pharmaceutical R&D, academic research, and diagnostic development focused on hypertension and related metabolic disorders.

Application

• Biomedical Research: Used as a reference standard and active agent in studies of the renin-angiotensin-aldosterone system (RAAS) and its role in hypertension, heart failure, and kidney disease.
• Pharmacological Studies: Employed in receptor binding assays (AT1 and AT2 receptors) and functional bioassays to evaluate drug candidates targeting angiotensin pathways.
• Diagnostic Development: Serves as a key antigen or calibrator in the development of immunoassays (e.g., ELISA, RIA) for measuring angiotensin peptides in biological samples.
• Cell Culture & Physiology: Applied in in vitro cell models to study cellular signaling, vascular tone, aldosterone secretion, and neuronal effects.
• Metabolic Research: Investigated for its effects on thirst, sodium appetite, and central nervous system functions related to fluid and electrolyte balance.
• Peptide Chemistry Reference: Utilized as a high-purity standard for analytical method development and validation in peptide analysis (HPLC, MS).

Basic Information

Product Name	Angiotensin III, Human
CAS No.	12687-51-3
Molecular Formula	C₄₁H₆₂N₁₂O₁₀
Molecular Weight	931.0 g/mol
Synonyms	Angiotensin III; Asp-Arg-Val-Tyr-Ile-His-Pro-Phe; [Des-Asp1]-Angiotensin II; DRVYIHPF; Angiotensin (2-8); Human Angiotensin III; Angiotensin 2-8 heptapeptide; Angiotensin III (human)
EINECS	Contact for details

Quality Control

Our Angiotensin III, Human is manufactured under strict quality systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, MS for identity confirmation, and amino acid analysis. Certificates of Analysis (COA) detailing purity, peptide content, and solvent residues are provided to ensure compliance with research-grade standards and support your regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccant and under an inert atmosphere. Allow the vial to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content (Amino Acid Analysis)	≥ 80%
Single Impurity (HPLC)	≤ 1.0%
Water Content (Karl Fischer)	≤ 5.0%
Acetate Content (HPLC/IC)	≤ 10.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.