Description

Cytochrome p-452 CAS NO 12679-56-0 is a specific isoform of the cytochrome P450 superfamily of heme-containing monooxygenase enzymes. This compound is critical for research into xenobiotic metabolism, drug-drug interactions, and the biosynthesis of endogenous compounds. It is primarily utilized by pharmaceutical R&D laboratories, academic research institutions, and biotechnology companies specializing in metabolic studies and toxicology screening.

Application

• Drug Metabolism and Pharmacokinetics (DMPK) Studies: Used as a reference standard or reagent in in vitro assays to evaluate the metabolic stability and clearance pathways of new chemical entities.
• Enzyme Inhibition/Screening Assays: Essential for identifying potential drug-drug interactions by testing new compounds for their ability to inhibit or induce specific CYP450 isoforms.
• Toxicology and Safety Assessment: Employed in research to understand the bioactivation of protoxins and the formation of reactive metabolites that may cause organ toxicity.
• Biochemical Research: Serves as a tool protein for studying enzyme kinetics, structure-function relationships, and the catalytic mechanism of monooxygenases.
• Diagnostic Kit Development: Can be incorporated into diagnostic kits or biosensors designed to measure metabolic enzyme activity in clinical or research settings.

Basic Information

Product Name	Cytochrome p-452
CAS No.	12679-56-0
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	CYP2B1; Cytochrome P450 2B1; Cytochrome P450 IIB1; Cytochrome P-450 PB-4; Cytochrome P-450b; Phenobarbital-inducible cytochrome P-450; P450 IIB1; P450 PB-4; P450b
EINECS	Contact for details

Quality Control

Our Cytochrome p-452 is produced and handled under stringent quality protocols to ensure batch-to-batch consistency and biological activity. Each lot is characterized for purity and specific activity. A comprehensive Certificate of Analysis (COA), detailing specifications such as purity (by SDS-PAGE), concentration, and functional activity, is provided with every shipment to support your critical research and development requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below for long-term stability. This product is hygroscopic (moisture-sensitive); allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and moisture uptake. Aliquot into single-use vials to avoid repeated freeze-thaw cycles.

Specification

Item	Specification
Appearance	Lyophilized powder or solution
Purity (SDS-PAGE)	≥ 90%
Specific Activity	Contact for details
Protein Concentration	Provided on COA
Buffer Composition	Provided on COA
Identification (Activity Assay)	Conforms

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.