Description

Angiotensin IV CAS NO 12676-15-2 is a bioactive peptide fragment derived from the renin-angiotensin system, specifically the cleavage product of Angiotensin II. This compound is of significant interest for its role as a selective ligand for the AT4 receptor, influencing cognitive function, memory, and cerebral blood flow. It is primarily utilized by pharmaceutical researchers, biotech companies, and academic institutions engaged in cardiovascular and neurological research, drug discovery, and the development of diagnostic tools.

Application

• Biomedical Research: Used as a critical reference standard and tool compound in studies of the renin-angiotensin system (RAS) and its physiological effects.
• Drug Discovery & Development: Serves as a lead compound or pharmacophore for designing novel therapeutics targeting cognitive disorders, hypertension, and heart failure.
• Neuroscience Studies: Applied in experimental models to investigate its effects on memory enhancement, learning, and neuronal protection.
• In Vitro Diagnostics (IVD): Employed in the development and calibration of immunoassays and ELISA kits for angiotensin pathway analysis.
• Receptor Binding Assays: Utilized to study the binding affinity and specificity of the AT4 (IRAP) receptor in competitive binding experiments.
• Academic & Clinical Research: Supports fundamental research into cardiovascular physiology, blood pressure regulation, and metabolic pathways.

Basic Information

Product Name	Angiotensin IV
CAS No.	12676-15-2
Molecular Formula	C₄₆H₆₆N₁₂O₁₁
Molecular Weight	963.1 g/mol
Synonyms	Angiotensin (3-8); Angiotensin IV (3-8); Angiotensin II (3-8); L-Valyl-L-tyrosyl-L-isoleucyl-L-histidyl-L-prolyl-L-phenylalanine; Val-Tyr-Ile-His-Pro-Phe; H-Val-Tyr-Ile-His-Pro-Phe-OH; AT4 receptor ligand
EINECS	Contact for details

Quality Control

Our Angiotensin IV is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity verification, mass spectrometry for identity confirmation, and amino acid analysis. We provide full traceability and Certificates of Analysis (COA) are available for every shipment, ensuring compliance with research-grade standards.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccation or storage under an inert atmosphere. Allow the vial to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Single Impurity (HPLC)	≤ 2.0%
Water Content (KF)	≤ 5.0%
Peptide Content	≥ 80%
Solubility	Soluble in water, DMSO, acetic acid

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.