Description

Bradykininogen CAS NO 12642-94-3 is a high-purity plasma protein and the precursor to the potent vasoactive peptide bradykinin. This compound is critical for research into the kallikrein-kinin system, which regulates blood pressure, inflammation, and pain signaling. It is an essential biochemical reagent for pharmaceutical R&D, clinical diagnostics, and advanced studies in cardiovascular and inflammatory diseases.

Application

• Biochemical Research: Fundamental studies on the kallikrein-kinin system, enzyme kinetics, and peptide hormone generation.
• Pharmaceutical Development: Target validation and screening for novel drugs targeting hypertension, angioedema, and chronic inflammatory conditions.
• Diagnostic Reagent Manufacturing: Used as a key component in immunoassay kits and calibrators for measuring kinin system activity.
• Academic & Clinical Studies: Investigating the role of bradykinin in pain pathways, sepsis, hereditary angioedema, and other physiological disorders.
• Reference Standard: Serves as a purified standard for quality control in related biopharmaceutical production and diagnostic applications.

Basic Information

Product Name	Bradykininogen
CAS No.	12642-94-3
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	Kininogen, High Molecular Weight Kininogen (HMWK); Low Molecular Weight Kininogen (LMWK); Bradykinin Precursor; α-2-Thiol Proteinase Inhibitor; Fitzgerald Factor; Williams Factor; Flaujeac Factor; Contact Activation Cofactor
EINECS	Contact for details

Quality Control

Our Bradykininogen is produced and tested under stringent quality management systems to ensure batch-to-batch consistency and reliability for critical research applications. Each lot is analyzed for purity, identity, and biological activity. A comprehensive Certificate of Analysis (COA) detailing specifications and test results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C. This material is hygroscopic (moisture-sensitive) and must be kept under dry conditions. For long-term storage, consider desiccation or inert atmosphere to preserve stability.

Specification

Item	Specification
Appearance	White to off-white powder or lyophilized solid
Identification (IR / HPLC)	Conforms to reference standard
Purity (SDS-PAGE / HPLC)	≥ 90% (Research Grade)
Protein Content (Biuret)	≥ 95% of total mass
Biological Activity	Functional assay dependent; Contact for details
Endotoxin Level (LAL)	< 1.0 EU/mg
Solubility	Soluble in aqueous buffers
Moisture Content (KF)	< 5.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.