Description

Spectrin CAS NO 12634-43-4 is a high-purity biochemical reagent recognized for its critical role in cytoskeletal research and diagnostic applications. This compound is essential for studying the structural integrity and mechanical properties of cell membranes, particularly in red blood cells. It is primarily utilized by research institutions, diagnostic laboratories, and biopharmaceutical companies engaged in hematology, cell biology, and the development of novel therapeutic agents.

Application

• Biomedical Research: Fundamental studies on erythrocyte membrane structure, elasticity, and disorders such as hereditary spherocytosis and elliptocytosis.
• Diagnostic Assay Development: Used as a key component or reference standard in immunoassays and kits for detecting membrane skeletal protein abnormalities.
• Cell Mechanics Studies: Investigation of the spectrin-actin network's role in maintaining cell shape, deformability, and resilience under shear stress.
• Pharmaceutical Screening: Target compound in drug discovery programs aimed at modulating membrane stability for therapeutic interventions.
• Quality Control Reagent: Serves as a standard in the quality control of related diagnostic products and research tools.
• Educational & Reference Material: Supplied to academic institutions for advanced coursework and laboratory training in biochemistry and cell biology.

Basic Information

Product Name	Spectrin
CAS No.	12634-43-4
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	Erythrocyte Spectrin; Spectrin, Human; Spectrin (Erythrocyte); Spectrin Protein; Spectrin (from human erythrocytes); Cytoskeletal Protein Spectrin; Membrane Skeletal Protein; Band 1 Protein (Erythrocyte)
EINECS	Contact for details

Quality Control

Our Spectrin is produced and handled under stringent quality management protocols to ensure batch-to-batch consistency and biological activity. Each lot undergoes comprehensive analytical testing, including purity assessment, identity confirmation, and functional activity checks. A Certificate of Analysis (COA) detailing specific test results is provided with every shipment to guarantee compliance with your research and application requirements.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below. Avoid repeated freeze-thaw cycles. Aliquot as received to maintain optimal activity.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder or solution
Identification (SDS-PAGE)	Corresponds to spectrin α and β chains
Purity (SDS-PAGE)	≥ 90%
Protein Content (BCA/Bradford)	≥ 1 mg/mL (or as specified)
Biological Activity	Functional in membrane binding assays
Endotoxin Level (LAL)	< 1.0 EU/mg
Solubility	Soluble in appropriate aqueous buffers

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.