Description

Insulin, Des-Asn(A21)-Des-Ala(B30)- is a high-purity, chemically modified insulin analog used as a critical intermediate in advanced pharmaceutical research and development. This compound is essential for studying insulin structure-activity relationships and for the synthesis of novel, long-acting insulin therapeutics. It is primarily utilized by biopharmaceutical companies, academic research institutions, and contract development and manufacturing organizations (CDMOs) focused on metabolic disease treatment.

Application

• Pharmaceutical Intermediate: Key starting material for the chemical synthesis and semi-synthesis of novel insulin analogs and bioconjugates.
• Metabolic Research: Used in biochemical and pharmacological studies to investigate insulin receptor binding, signaling pathways, and mechanisms of action.
• Drug Discovery: Serves as a core scaffold for developing next-generation, ultra-long-acting basal insulin products with improved pharmacokinetic profiles.
• Reference Standard: Employed as an analytical standard in quality control laboratories for the identification and quantification of related insulin products.
• Process Development: Utilized in the development and optimization of manufacturing processes for recombinant insulin analogs.

Basic Information

Product Name	Insulin, Des-Asn(A21)-Des-Ala(B30)-
CAS No.	12584-26-8
Molecular Formula	C254H377N65O76S6
Molecular Weight	~5807.5 g/mol
Synonyms	Des(B30) Insulin; Des-Ala(B30)-Insulin; Insulin Des-Ala B30; Insulin (human) Des-Ala(B30); Des-Asn(A21),Des-Ala(B30)-Insulin; Insulin analog (A21-Asn deleted, B30-Ala deleted); [Des-AsnA21, Des-AlaB30]-Insulin
EINECS	Contact for details

Quality Control

Our Insulin, Des-Asn(A21)-Des-Ala(B30)- is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including HPLC for purity and related substances, mass spectrometry for identity confirmation, and biological activity assays to ensure it meets the stringent requirements for pharmaceutical research. Certificates of Analysis (COA) detailing all specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive). For long-term storage, keep desiccated. Allow the vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥ 95.0%
Related Substances (HPLC)	Individual impurity ≤ 2.0%
Water Content (KF)	≤ 10.0%
Biological Potency	80% - 120% of reference standard
Bacterial Endotoxins	< 10 EU/mg

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.