Description

Boc-D-Tic-Oh is a protected, non-proteinogenic amino acid derivative widely used as a critical building block in peptide synthesis. This compound is essential for introducing the constrained 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid (Tic) moiety with D-configuration into peptide chains, which is valuable for modulating biological activity and stability. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel therapeutic peptides, peptidomimetics, and bioactive probes.

Application

• Pharmaceutical Intermediates: A key chiral synthon for the solid-phase and solution-phase synthesis of peptide-based drug candidates.
• Peptidomimetic Research: Used to incorporate conformationally restricted amino acid analogs to study structure-activity relationships (SAR) and enhance metabolic stability.
• Bioconjugation & Probe Development: Serves as a specialized component for creating labeled peptides or affinity tags for biochemical assays.
• Academic & R&D Laboratories: Employed in fundamental research exploring peptide chemistry, enzyme inhibitors, and receptor ligands.

Basic Information

Product Name	Boc-D-Tic-Oh
CAS No.	11592-35-1
Molecular Formula	C₁₅H₁₉NO₄
Molecular Weight	277.32 g/mol
Synonyms	(R)-2-((tert-Butoxycarbonyl)amino)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid; Boc-D-1,2,3,4-Tetrahydroisoquinoline-3-carboxylic acid; N-(tert-Butoxycarbonyl)-D-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid; Boc-D-Tic-OH; N-Boc-D-tetrahydroisoquinoline-3-carboxylic acid; D-Tic(Boc)-OH
EINECS	Contact for details

Quality Control

Our Boc-D-Tic-Oh is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis, and identity confirmation, to ensure it meets the high standards required for pharmaceutical research. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee batch-to-batch consistency and traceability.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.