Description

Cathepsin A is a lysosomal serine carboxypeptidase with significant proteolytic activity, playing a crucial role in protein metabolism and cellular regulation. Its primary commercial value lies in its application as a high-purity biochemical reagent for advanced life science research and diagnostic development. This enzyme is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and diagnostic sectors, particularly for studies involving lysosomal function, protein degradation pathways, and biomarker discovery.

Application

• Biochemical Research: Used as a key reagent in enzymatic assays to study lysosomal proteolysis, protein catabolism, and intracellular signaling pathways.
• Pharmaceutical Development: Employed in target validation and screening assays for drug discovery programs focused on lysosomal storage disorders and related metabolic diseases.
• Diagnostic Kit Manufacturing: Serves as a critical component in the development of enzyme-based diagnostic tests and kits for clinical laboratories.
• Cell Biology Studies: Utilized to investigate cellular processes such as apoptosis, autophagy, and antigen processing due to its specific proteolytic function.
• Proteomics: Applied in protein sequencing and peptide mapping workflows as a specific carboxypeptidase for C-terminal analysis.
• Enzyme Characterization: Acts as a standard or substrate in comparative studies of serine protease inhibitors and enzyme kinetics.

Basic Information

Product Name	Cathepsin A
CAS No.	11104-54-4
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	Lysosomal Protective Protein; Serine Carboxypeptidase 1; Cathepsin A1; Carboxypeptidase C; Cathepsin A Protective Protein; PPCA; CLN2 Activator; Lysosomal Carboxypeptidase A; EC 3.4.16.5
EINECS	Contact for details

Quality Control

Our Cathepsin A is produced under strict quality management systems to ensure batch-to-batch consistency and high biological activity. Each lot undergoes comprehensive analytical testing, including activity assays, purity assessment via electrophoresis, and specificity checks. A detailed Certificate of Analysis (COA) documenting purity, specific activity, and stability is provided with every shipment to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below for long-term stability. This product is hygroscopic (moisture-sensitive). For optimal performance, avoid repeated freeze-thaw cycles and aliquot the product upon receipt. Keep the container tightly sealed in a dry environment.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (Activity)	Conforms
Specific Activity	≥ [Value] units/mg protein
Purity (SDS-PAGE)	≥ 90%
Protein Content (Bradford)	≥ [Value] mg/vial
pH (in solution)	6.0 - 7.5
Endotoxin (LAL)	< 1.0 EU/μg
Biological Activity	Conforms to reference standard

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.