Description

Toxin, Snake From Laticauda*Semifasciata (Erabutoxin) is a highly purified, short-chain neurotoxic peptide isolated from the venom of the sea snake *Laticauda semifasciata*. This compound is a critical research-grade biochemical tool for studying the structure and function of nicotinic acetylcholine receptors (nAChRs) at the neuromuscular junction. It is essential for neuroscience and pharmacology research, as well as for the development of diagnostic assays and potential therapeutic leads targeting cholinergic pathways.

Application

• Neuroscience Research: As a specific and potent antagonist of muscle-type nicotinic acetylcholine receptors, used to study synaptic transmission, receptor desensitization, and channel block mechanisms.
• Pharmacological Tool Development: Serves as a reference standard and key reagent in the development and validation of high-throughput screening (HTS) assays for drug discovery programs targeting the cholinergic system.
• Structural Biology Studies: Used in X-ray crystallography and NMR spectroscopy to elucidate the three-dimensional structure of toxin-receptor complexes, providing insights into molecular recognition.
• Diagnostic Reagent: Employed in the development of sensitive immunoassays and biosensors for the detection of specific neurotoxins or for studying autoimmune conditions like myasthenia gravis.
• Comparative Venom Research: Acts as a benchmark for studying the evolution, diversity, and specificity of neurotoxic components across different elapid snake venoms.
• Educational & Reference Material: Supplied to academic institutions and reference laboratories for advanced coursework and as a certified reference material in analytical testing.

Basic Information

Product Name	Toxin, Snake From Laticauda*Semifasciata (Erabutoxin)
CAS No.	11094-61-4
Molecular Formula	C~180~H~274~N~52~O~55~S~7
Molecular Weight	~ 4200 Da (monoisotopic)
Synonyms	Erabutoxin; Erabutoxin a; Laticauda semifasciata neurotoxin; Sea snake toxin; Short-chain neurotoxin; Acetylcholine receptor antagonist; α-Neurotoxin; Ls III; LsNTx
EINECS	Contact for details

Quality Control

Our Erabutoxin is produced and purified under stringent conditions to ensure batch-to-batch consistency and high biological activity. Quality is verified through a comprehensive suite of analytical techniques. A detailed Certificate of Analysis (COA) is provided with each batch, confirming identity, purity, and specific activity. Our quality system supports research requiring reliable and well-characterized biochemical tools.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store lyophilized material at -20°C or below. Reconstituted solutions should be aliquoted to avoid repeated freeze-thaw cycles and stored at -70°C or below. The product is hygroscopic (moisture-sensitive); ensure containers are sealed under anhydrous conditions after each use.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95.0%
Specific Activity	Contact for details
Protein Content (UV)	≥ 90.0%
Endotoxin Level (LAL)	< 1.0 EU/µg
Solubility	Soluble in water or aqueous buffers
Moisture Content (KF)	≤ 5.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.