Description

Proinsulin is a single-chain polypeptide precursor to the vital metabolic hormone insulin. This high-purity intermediate is critical for research into insulin biosynthesis, diabetes pathophysiology, and the development of novel therapeutic and diagnostic approaches. It is an essential biochemical tool for pharmaceutical R&D, academic research institutions, and biotechnology companies focused on endocrinology and metabolic disease.

Application

• Biochemical Research: Fundamental studies on insulin synthesis, folding, and post-translational processing.
• Diabetes Research: Investigation of β-cell function, autoimmune responses in type 1 diabetes, and insulin resistance mechanisms.
• Reference Standard: Used as a calibrant or control in immunoassays (e.g., ELISA, RIA) to measure proinsulin or C-peptide levels in clinical and preclinical samples.
• Pharmaceutical Development: Serves as a key starting material or intermediate in the research and production of insulin and insulin analogs.
• Diagnostic Kit Production: Essential component in the manufacture of diagnostic kits for assessing pancreatic β-cell health and insulinoma.
• Cell Culture & In Vitro Studies: Used in metabolic studies and to stimulate insulin-responsive cells under controlled experimental conditions.

Basic Information

Product Name	Proinsulin
CAS No.	11062-03-6
Molecular Formula	C256H387N65O77S6
Molecular Weight	~9397.5 g/mol
Synonyms	Human Proinsulin; Proinsulin Human; Insulin Precursor; Preproinsulin (processed form); 11062-03-6; Proinsulin (BIOTIN); Proinsulin (HUMAN); Proinsulin (PORCINE)
EINECS	Contact for details

Quality Control

Our Proinsulin is produced and tested under stringent quality management systems to ensure batch-to-batch consistency and reliability for critical research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and biological activity. We adhere to relevant guidelines for research-grade biochemicals, ensuring suitability for use in pharmaceutical development and diagnostic manufacturing.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to reach room temperature in a desiccator before opening to prevent condensation and moisture uptake. For long-term storage, keep desiccated at -70°C.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95.0%
Biological Activity	Assessed by in vitro assay
Water Content (KF)	≤ 5.0%
Endotoxin	< 10 EU/mg

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.