Description

A-Crystallin is a highly specialized protein belonging to the small heat shock protein (sHSP) family, known for its crucial role as a molecular chaperone. This compound is essential for maintaining cellular integrity by preventing the aggregation of misfolded proteins under conditions of stress. It is a critical material for researchers and developers in the pharmaceutical, biotechnology, and life science research sectors, particularly for studies focused on neuroprotection, cataract formation, and protein stabilization.

Application

• Biomedical Research: Used as a key reagent in studies investigating protein aggregation diseases, such as Alzheimer's, Parkinson's, and amyotrophic lateral sclerosis (ALS).
• Ophthalmology Research: Fundamental for in-vitro studies on lens transparency and the pathophysiology of cataracts, where α-crystallin is a major structural component.
• Drug Discovery & Development: Serves as a target or a protective agent in screening platforms for neuroprotective and anti-aggregation therapeutics.
• Biochemical Assays: Employed in chaperone activity assays to study protein-protein interactions and folding pathways.
• Diagnostic Development: Potential use in the development of biomarkers or immunoassays related to cellular stress responses.
• Stabilization Agent: Investigated for its potential to stabilize other therapeutic proteins in formulation development.

Basic Information

Item	Details
Product Name	A-Crystallin
CAS No.	11046-99-4
Molecular Formula	Contact for details
Molecular Weight	~20 kDa (Subunit)
Synonyms	α-Crystallin; CRYA1/CRYA2; HspB4/HspB5; Small Heat Shock Protein β-5; 20 kDa Protein; Lens α-Crystallin; Molecular Chaperone α-Crystallin; Crystallin, Alpha A Chain; Crystallin, Alpha B Chain
EINECS	Contact for details

Quality Control

Our A-Crystallin is produced and handled under stringent conditions to ensure batch-to-batch consistency and biological activity. Each lot is subjected to a comprehensive suite of analytical tests. Certificates of Analysis (COA) detailing purity, identity, and functional activity are available upon request, supporting compliance with rigorous research and development standards.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below for long-term stability. This product is hygroscopic (moisture-sensitive). Allow the vial to reach room temperature in a desiccator before opening to prevent condensation and moisture uptake. For extended storage, consider under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (SDS-PAGE)	Corresponds to ~20 kDa band
Purity (HPLC)	≥ 95%
Protein Content (BCA)	≥ 90%
Endotoxin Level (LAL)	< 1.0 EU/mg
Bioburden	To specification
Chaperone Activity (Assay)	To specification
Solubility	Soluble in appropriate aqueous buffers

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.