Description

Tetanospasmin is a potent neurotoxin protein produced by the bacterium *Clostridium tetani*. This high-purity biological compound is critical for advanced research and diagnostic applications in neuroscience and immunology. It is primarily utilized by pharmaceutical R&D laboratories, academic research institutions, and specialized diagnostic manufacturers for studying neuromuscular junction function, developing antitoxins, and creating reference standards.

Application

• Neuroscience Research: A key tool for studying the mechanisms of neurotransmitter release inhibition at the presynaptic membrane, synaptic vesicle recycling, and the pathophysiology of tetanus.
• Vaccine & Antitoxin Development: Serves as a critical antigen and reference standard in the research and quality control of tetanus vaccines and therapeutic antitoxins.
• Diagnostic Reagent Production: Used in the development and calibration of highly sensitive immunoassays and diagnostic kits for tetanus and related neurological studies.
• Pharmacological Studies: Employed in vitro to investigate botulinum neurotoxin mechanisms and to screen for potential therapeutic compounds that modulate neurotoxin activity.
• Cell Biology & Biochemistry: Utilized as a specific probe to study intracellular trafficking, protein translocation, and the role of clostridial neurotoxins in cellular processes.

Basic Information

Product Name	Tetanospasmin
CAS No.	11032-48-7
Molecular Formula	Contact for details
Molecular Weight	Approx. 150 kDa (Contact for details)
Synonyms	Tetanus Toxin; Tetanus Neurotoxin; TeNT; Clostridium tetani Neurotoxin; Spasmogenic Toxin; Tetanotoxin; Tetanus Exotoxin
EINECS	Contact for details

Quality Control

Our Tetanospasmin is produced and handled under stringent conditions to ensure the highest standards of purity and biological activity for research use. Each batch is subjected to a comprehensive suite of analytical tests, including activity assays, purity analysis, and identity confirmation. A Certificate of Analysis (COA) detailing specific results for purity, protein concentration, and biological activity is provided with every shipment to ensure full traceability and compliance with your research protocols.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store frozen at -20°C or below. Avoid repeated freeze-thaw cycles. Handle in accordance with good laboratory practice and appropriate biosafety level (BSL-2) guidelines.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder or solution
Identification (SDS-PAGE / Immunoassay)	Conforms
Purity (HPLC)	≥ 95%
Protein Content	Specified on COA
Biological Activity (Mouse LD50 or Cell-based Assay)	Specified on COA
Endotoxin Level (LAL)	< 10 EU/mg
Sterility (Membrane Filtration)	Sterile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.