Description

5,5'-[Decamethylenebis(Carbonylimino)]Bis(n-Methyl-2,4,6-Triiodoisophthalamic Acid) is a high-purity, iodinated organic compound primarily used as a key intermediate in the synthesis of advanced X-ray contrast media. Its complex molecular structure, featuring multiple iodine atoms, is critical for achieving the high radiopacity required in modern diagnostic imaging agents. This product is essential for pharmaceutical manufacturers and research institutions developing next-generation non-ionic, low-osmolar contrast agents to enhance patient safety and diagnostic clarity.

Application

• Pharmaceutical Intermediate: Primary building block for the synthesis of non-ionic X-ray contrast agents like Iopamidol, Ioversol, and Iopromide.
• Diagnostic Imaging Research: Used in R&D to develop novel iodinated compounds with improved pharmacokinetic profiles and reduced nephrotoxicity.
• Contrast Media Production: Critical raw material in the commercial-scale manufacturing of injectable contrast solutions for computed tomography (CT) and angiography.
• Chemical Synthesis: Serves as a versatile intermediate for creating specialized iodinated aromatic compounds for various research applications.

Basic Information

Product Name	5,5'-[Decamethylenebis(Carbonylimino)]Bis(n-Methyl-2,4,6-Triiodoisophthalamic Acid)
CAS No.	10397-78-1
Molecular Formula	C32H28I6N4O10
Molecular Weight	1559.91 g/mol
Synonyms	5,5'-[Decane-1,10-diylbis(carbonylimino)]bis(N-methyl-2,4,6-triiodoisophthalamic acid); Iopamidol Intermediate; Ioversol Intermediate; 1,10-Bis[(2,4,6-triiodo-3,5-bis[(methylcarbamoyl)carbamoyl]phenyl]carbamoyl]decane; Bis-acid precursor for non-ionic contrast media; Decamethylenebis(carbonylimino)bis(triiodoisophthalamic acid) derivative
EINECS	Contact for details

Quality Control

Our production of this critical pharmaceutical intermediate adheres to strict cGMP (current Good Manufacturing Practice) guidelines to ensure batch-to-batch consistency and traceability. Every lot undergoes comprehensive analytical testing, including HPLC for purity and assay, residual solvent analysis, and heavy metal screening, to meet the exacting standards of the pharmaceutical industry. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming compliance with agreed specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Loss on Drying	≤ 1.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.