Description

(Boc-Cys-OH)2 is a high-purity, protected amino acid derivative essential for modern peptide synthesis. This compound serves as a critical building block, enabling the controlled introduction of cysteine residues while protecting the reactive thiol group during complex coupling reactions. It is primarily utilized by research institutions and pharmaceutical manufacturers developing therapeutic peptides, APIs, and biochemical tools where precise molecular assembly is required.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key intermediate for the controlled incorporation of cysteine into peptide chains, crucial for forming disulfide bridges that define protein structure and stability.
• Pharmaceutical Intermediate: Used in the research and development of peptide-based active pharmaceutical ingredients (APIs) for various therapeutic areas.
• Bioconjugation & Protein Engineering: Facilitates site-specific modifications and labeling of proteins and peptides via the protected thiol functionality.
• Chemical Biology Research: Employed as a reagent in studying protein folding, structure-activity relationships (SAR), and molecular recognition processes.
• Ligation Chemistry: Acts as a precursor in native chemical ligation (NCL) and other convergent synthesis strategies for large peptides and small proteins.
• Protecting Group Strategy: The tert-butoxycarbonyl (Boc) group provides orthogonal protection compatible with Fmoc-based synthesis protocols, offering flexibility in synthetic routes.

Basic Information

Product Name	(Boc-Cys-OH)2
CAS No.	10389-65-8
Molecular Formula	C16H28N2O8S2
Molecular Weight	440.53 g/mol
Synonyms	N-α-Boc-L-cystine; N-α-tert-Butoxycarbonyl-L-cystine; Boc-L-Cystine; (2R,2'R)-3,3'-Disulfanediylbis(2-((tert-butoxycarbonyl)amino)propanoic acid); tert-Butyloxycarbonyl-L-cystine; Boc-Cys-OH Dimer; N-Boc-L-cystine; N-tert-Butoxycarbonylcystine
EINECS	Contact for details

Quality Control

Our (Boc-Cys-OH)2 is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research and pharmaceutical applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to cGMP principles where applicable, and our quality protocols are designed to meet the stringent requirements of advanced synthetic chemistry.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider storing under an inert atmosphere such as argon or nitrogen to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Optical Rotation [α]	Contact for details
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.