Description

2'-Deoxy-5-Fluorocytidine is a fluorinated nucleoside analog of significant importance in pharmaceutical research and development. This compound serves as a critical intermediate in the synthesis of active pharmaceutical ingredients (APIs) and prodrugs, particularly in the field of oncology. It is primarily utilized by research institutions, pharmaceutical manufacturers, and fine chemical suppliers engaged in the development of antiviral and anticancer therapeutics. The consistent quality and reliable supply of this high-purity intermediate are essential for advancing clinical research and ensuring robust manufacturing processes.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of chemotherapeutic agents, such as capecitabine and other fluoropyrimidine-based drugs.
• Antiviral Research: Used in the development and study of nucleoside analogs targeting viral replication mechanisms.
• Biochemical Research: Serves as a substrate or inhibitor in enzymatic studies related to DNA synthesis and repair pathways.
• Prodrug Synthesis: Essential precursor for creating orally bioavailable prodrugs designed for targeted drug delivery.
• Reference Standard: Employed as a high-purity analytical standard in quality control laboratories for HPLC, LC-MS, or NMR method development.
• Oncology R&D: Investigated for its role in modulating cell proliferation and as a component in novel combination therapies.

Basic Information

Product Name	2'-Deoxy-5-Fluorocytidine
CAS No.	10356-76-0
Molecular Formula	C9H12FN3O4
Molecular Weight	245.21 g/mol
Synonyms	5-Fluoro-2'-deoxycytidine; 5-Fluoro-2'-deoxycytidine; 5-FdCyd; 5-Fluoro-2'-deoxycytidine; 2'-Deoxy-5-fluorocytidine; 5-Fluoro-2'-deoxycytidine; NSC 10356; 5-Fluoro-2'-deoxycytidine; 5-Fluoro-2'-deoxycytidine
EINECS	Contact for details

Quality Control

Our 2'-Deoxy-5-Fluorocytidine is manufactured under strict quality management systems to ensure it meets the stringent requirements for pharmaceutical intermediates. Each batch is subjected to comprehensive analytical testing, including HPLC for purity and identity confirmation via IR and NMR spectroscopy. We provide Certificates of Analysis (COA) with each shipment, detailing all relevant specifications. Our quality commitment aligns with cGMP principles where applicable, ensuring traceability and consistency for critical research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.