Description

Chlorprothixene Sulfoxide is a key pharmaceutical intermediate and metabolite of the antipsychotic agent chlorprothixene. This compound is essential for research and development in the pharmaceutical industry, particularly for analytical method development, impurity profiling, and metabolic studies. It is primarily utilized by pharmaceutical manufacturers, contract research organizations (CROs), and academic research institutions focused on neuropharmacology and drug metabolism.

Application

• Pharmaceutical Reference Standard: Serves as a certified reference material (CRM) for the quality control and assay validation of chlorprothixene-based drug products.
• Metabolite Research: Critical for in-vitro and in-vivo studies investigating the metabolic pathways, pharmacokinetics, and bioavailability of chlorprothixene.
• Impurity Identification and Profiling: Used as a known impurity standard to monitor and control the quality of active pharmaceutical ingredients (APIs) during synthesis and formulation.
• Analytical Method Development: Employed in developing and calibrating analytical techniques such as HPLC, LC-MS, and GC-MS for precise quantification.
• Pharmacological Studies: Utilized in preclinical research to understand the structure-activity relationship (SAR) and the biological impact of sulfoxide metabolites.
• Regulatory Compliance and Documentation: Supports regulatory filings (e.g., for FDA, EMA) by providing necessary data on drug impurities and degradation products.

Basic Information

Product Name	Chlorprothixene Sulfoxide
CAS No.	10120-63-5
Molecular Formula	C18H18ClNOS
Molecular Weight	331.86 g/mol
Synonyms	2-Chloro-9-[3-(dimethylamino)propylidene]thioxanthene 10,10-Dioxide; Chlorprothixene S-Oxide; Chlorprothixen Sulfoxide; cis-Chlorprothixene Sulfoxide; trans-Chlorprothixene Sulfoxide; NSC 115079; Thioxanthene-2-chloro-9-(3-(dimethylamino)propylidene)-, S,S-dioxide
EINECS	Contact for details

Quality Control

Our Chlorprothixene Sulfoxide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including identification by IR and NMR, purity assay by HPLC, and control of specified impurities. We provide full traceability and Certificates of Analysis (COA) are available for all shipments, ensuring compliance with relevant pharmacopeial and internal specifications for research and pharmaceutical use.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The compound is light-sensitive; prolonged exposure to light should be avoided to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Individual impurity: ≤ 0.5% Total impurities: ≤ 2.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.