Description

Prochlorperazine Sulfoxide is a key pharmaceutical intermediate and metabolite of the antipsychotic drug prochlorperazine. This compound is of significant importance for research and development in neuropharmacology and analytical chemistry. It is primarily utilized by pharmaceutical manufacturers, contract research organizations (CROs), and analytical laboratories for method development, impurity profiling, and metabolic studies.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis and research of phenothiazine-derived antipsychotic agents.
• Reference Standard: Used as a certified reference material (CRM) in HPLC and LC-MS methods for drug purity testing and quality control.
• Metabolite Studies: Essential for in-vitro and in-vivo pharmacokinetic research to understand the metabolic pathways of prochlorperazine.
• Impurity Profiling: Serves as a known impurity standard to ensure the safety and efficacy of final drug products according to ICH guidelines.
• Analytical Method Development: Used by QC laboratories to develop and validate stability-indicating assay methods.

Basic Information

Product Name	Prochlorperazine Sulfoxide
CAS No.	10078-27-0
Molecular Formula	C₂₀H₂₄ClN₃OS
Molecular Weight	389.94 g/mol
Synonyms	2-Chloro-10-[3-(4-methylpiperazin-1-yl)propyl]-10H-phenothiazine 5-oxide; Compazine Sulfoxide; Prochlorperazine S-oxide; NSC 169854; 5-Chloro-2-[3-(4-methyl-1-piperazinyl)propyl]-10H-phenothiazine 5-oxide; Prochlorperazine Sulfoxide (Major Metabolite); 1-{3-[2-Chloro-10H-phenothiazin-10-yl]propyl}-4-methylpiperazine 5-oxide
EINECS	Contact for details

Quality Control

Our Prochlorperazine Sulfoxide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including identification by spectroscopic methods (IR, NMR), purity determination by HPLC, and control of related substances. We provide full traceability and Certificates of Analysis (COA) are available for all shipments, ensuring compliance with research and pharmaceutical intermediate standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Keep the container tightly sealed in a dry environment to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single unknown impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.