Description

Z-Tyr(Tbu)-Osu is a protected tyrosine derivative widely used as a key building block in solid-phase peptide synthesis (SPPS). Its value lies in the orthogonal protection strategy it provides, where the tert-butyl (Tbu) group safeguards the phenolic hydroxyl side chain, and the N-terminal is protected by a benzyloxycarbonyl (Z) group, allowing for selective deprotection during complex peptide assembly. This compound is essential for researchers and manufacturers in the pharmaceutical and biotechnology sectors developing therapeutic peptides, diagnostic agents, and biochemical tools.

Application

• Solid-Phase Peptide Synthesis (SPPS): A fundamental reagent for the controlled, sequential addition of tyrosine residues in automated and manual peptide synthesis.
• Pharmaceutical Intermediate: Used in the research and production of peptide-based active pharmaceutical ingredients (APIs) and drug candidates.
• Bioconjugation: Serves as a precursor for creating tyrosine-modified linkers or probes used in antibody-drug conjugates (ADCs) and other bioconjugation strategies.
• Biochemical Research: Employed in academic and industrial labs to synthesize custom peptides for structure-activity relationship (SAR) studies, enzyme substrates, and receptor ligands.
• Protecting Group Chemistry: Demonstrates the application of orthogonal protecting groups (Z and tBu) in complex organic synthesis, valuable for educational and methodological development.

Basic Information

Product Name	Z-Tyr(Tbu)-Osu
CAS No.	10068-67-4
Molecular Formula	C25H30N2O7
Molecular Weight	470.52 g/mol
Synonyms	N-[(Benzyloxy)carbonyl]-O-tert-butyl-L-tyrosine N-Hydroxysuccinimide Ester; Z-O-tert-butyl-L-tyrosine N-hydroxysuccinimide ester; N-Cbz-O-tert-butyl-L-tyrosine N-hydroxysuccinimide ester; Nα-Z-O-tert-butyl-L-tyrosine N-hydroxysuccinimide ester; N-Carbobenzoxy-O-tert-butyl-L-tyrosine N-hydroxysuccinimide ester; N-Hydroxysuccinimide ester of Z-Tyr(O-tBu)-OH; Z-Tyr(O-tBu)-OSu; Z-L-Tyrosine(O-t-butyl)-N-hydroxysuccinimide ester
EINECS	Contact for details

Quality Control

Our Z-Tyr(Tbu)-Osu is produced under strict quality management protocols to ensure batch-to-batch consistency and high purity suitable for sensitive synthetic applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis for enantiomeric excess, and identity confirmation via IR and NMR spectroscopy. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment to support your quality assurance and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This compound is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent decomposition. For long-term storage, consider storing under an inert atmosphere such as argon or nitrogen.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Specific Rotation	Contact for details
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.