Description

Z-Thr(Tbu)-Osu CAS NO 10068-65-2 is a protected amino acid derivative, specifically the N-benzyloxycarbonyl (Z) protected form of O-tert-butyl-L-threonine activated as an N-hydroxysuccinimide (Osu) ester. This compound is a critical building block in solid-phase peptide synthesis (SPPS), offering enhanced coupling efficiency and reduced racemization risk. It is primarily utilized by research institutions and pharmaceutical companies for the development of novel peptides, therapeutic agents, and biochemical probes.

Application

• Solid-Phase Peptide Synthesis (SPPS): As a key intermediate for the controlled, sequential addition of threonine residues with orthogonal side-chain protection.
• Pharmaceutical Research: For the synthesis of peptide-based drug candidates, hormones, and enzyme inhibitors.
• Bioconjugation: Used to introduce threonine motifs or specific functional groups onto proteins, antibodies, or other biomolecules.
• Combinatorial Chemistry: A valuable reagent in libraries for high-throughput screening of bioactive peptides.
• Academic & Industrial R&D: Fundamental research in peptide chemistry, structure-activity relationship (SAR) studies, and material science.
• Production of Custom Peptides: Essential for CROs and CDMOs manufacturing bespoke peptides for clients worldwide.

Basic Information

Product Name	Z-Thr(Tbu)-Osu
CAS No.	10068-65-2
Molecular Formula	C20H26N2O7
Molecular Weight	406.43 g/mol
Synonyms	Nα-Benzyloxycarbonyl-O-tert-butyl-L-threonine N-hydroxysuccinimide ester; Z-O-tert-butyl-L-threonine N-hydroxysuccinimide ester; N-Cbz-O-tert-butyl-L-threonine succinimidyl ester; (2,5-Dioxopyrrolidin-1-yl) (2S,3R)-3-[(2-methylpropan-2-yl)oxy]-2-[(phenylmethoxy)carbonylamino]butanoate; Cbz-Thr(tBu)-OSu; Z-Thr(OtBu)-OSu; Z-L-Thr(tBu)-OSu; Z-Thr(tBu)-OSu ester
EINECS	Contact for details

Quality Control

Our Z-Thr(Tbu)-Osu is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity and consistency, meeting the stringent requirements of peptide synthesis. Certificates of Analysis (COA) detailing purity, chiral integrity, and impurity profiles are provided with every shipment to guarantee reliable performance in your critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a freezer at -20°C or below. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and reactivity. Allow the sealed container to equilibrate to room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Optical Rotation [α]D20	Contact for details
Water Content (KF)	≤0.5%
Heavy Metals	≤10 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.