Description

(+)-2-(Acetylamino)-3-Mercaptopropionamide CAS NO 10061-64-0 is a high-purity chiral intermediate featuring both an amide and a thiol functional group, making it a valuable building block for complex organic synthesis. Its primary commercial value lies in its role as a key precursor for the development of pharmaceuticals, particularly in the synthesis of enzyme inhibitors and other bioactive molecules. This compound is essential for research and development laboratories, pharmaceutical manufacturers, and fine chemical producers focused on creating novel therapeutic agents and advanced materials.

Application

• Pharmaceutical Intermediate: A critical chiral building block for the synthesis of enzyme inhibitors, including cysteine protease inhibitors and angiotensin-converting enzyme (ACE) inhibitors.
• Peptide Mimetics Research: Used in the design and synthesis of peptidomimetics and constrained peptides due to its thiol and amide functionalities.
• Bioconjugation Chemistry: The reactive thiol group enables its use in site-specific protein and antibody-drug conjugate (ADC) linker technologies.
• Asymmetric Synthesis: Serves as a chiral auxiliary or starting material in stereoselective reactions to introduce sulfur-containing stereocenters.
• Chemical Biology Probes: Utilized in the development of activity-based probes (ABPs) for studying enzyme function and mechanism.
• Material Science: Potential monomer or cross-linking agent in the development of specialty polymers with unique properties.

Basic Information

Product Name	(+)-2-(Acetylamino)-3-Mercaptopropionamide
CAS No.	10061-64-0
Molecular Formula	C5H10N2O2S
Molecular Weight	162.21 g/mol
Synonyms	N-Acetyl-L-cysteinamide; L-N-Acetylcysteinamide; (R)-2-Acetamido-3-mercaptopropanamide; (+)-N-Acetylcysteinamide; Ac-Cys-NH2; N-Acetylcysteine amide; N-Acetyl-L-cysteine amide; 2-(Acetylamino)-3-mercaptopropanamide
EINECS	Contact for details

Quality Control

Our (+)-2-(Acetylamino)-3-Mercaptopropionamide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity analysis by HPLC, to ensure it meets the high standards required for pharmaceutical R&D and production. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting identity, purity, and impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at 2-8°C in a dry, cool place. Due to its hygroscopic and easily oxidized nature, prolonged exposure to air, moisture, or elevated temperatures should be avoided to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.