Description

(R)-(+)-α-Hydroxybenzene-Acetonitrile is a high-purity chiral building block and key intermediate in organic synthesis. This compound matters for its role in the stereoselective production of pharmaceuticals and fine chemicals, where its specific (R)-(+) enantiomeric configuration is critical for biological activity and process efficacy. It is primarily needed by research institutions and manufacturers in the pharmaceutical, agrochemical, and advanced material sectors for developing active pharmaceutical ingredients (APIs), chiral catalysts, and specialty polymers.

Application

• Pharmaceutical Intermediate: A crucial chiral synthon for the synthesis of enantiomerically pure drugs, particularly in β-blocker and antidepressant research.
• Agrochemical Synthesis: Used in the production of chiral pesticides and herbicides where specific stereochemistry enhances efficacy and reduces environmental impact.
• Asymmetric Catalysis: Serves as a precursor or ligand in the development of chiral catalysts for stereoselective chemical transformations.
• Fine Chemical Production: Employed in the manufacture of specialty chemicals, flavors, and fragrances requiring high enantiomeric purity.
• Academic & Industrial Research: A valuable reagent for methodological development in organic chemistry and process chemistry R&D.
• Material Science: Potential monomer or modifier in the synthesis of chiral polymers and advanced functional materials.

Basic Information

Product Name	(R)-(+)-α-Hydroxybenzene-Acetonitrile
CAS No.	10020-96-9
Molecular Formula	C9H9NO
Molecular Weight	147.17 g/mol
Synonyms	(R)-(+)-Mandelonitrile; (R)-Mandelonitrile; (R)-(+)-2-Hydroxy-2-phenylacetonitrile; (R)-α-Hydroxybenzeneacetonitrile; (R)-2-Hydroxy-2-phenylethanenitrile; (R)-Cyanohydrin of Benzaldehyde; (R)-Benzaldehyde cyanohydrin; D-Mandelonitrile
EINECS	233-026-5

Quality Control

Our (R)-(+)-α-Hydroxybenzene-Acetonitrile is produced under strict quality management systems to ensure batch-to-batch consistency and high enantiomeric purity. Each lot undergoes comprehensive analytical testing, including chiral HPLC for enantiomeric excess (ee) determination, identity confirmation by IR and NMR, and purity assessment. Certificates of Analysis (COA) detailing all specifications are provided and can be tailored to meet specific customer or regulatory requirements (e.g., ICH guidelines).

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, containers should be opaque or stored in dark conditions.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.