Description

2-Hydroxy Desipramine is a key metabolite and reference standard of the tricyclic antidepressant desipramine. This compound is essential for pharmaceutical research and development, particularly in the study of drug metabolism, pharmacokinetics, and bioanalytical method validation. It is primarily utilized by pharmaceutical manufacturers, contract research organizations (CROs), and academic institutions engaged in neuroscience and analytical chemistry.

Application

• Pharmaceutical Reference Standard: Serves as a certified standard for the identification and quantification of desipramine and its metabolites in drug substance and finished product analysis.
• Metabolite Research: Critical for in vitro and in vivo studies investigating the metabolic pathways, pharmacokinetics, and pharmacodynamics of desipramine.
• Bioanalytical Method Development: Used as a calibrant and quality control sample in the development and validation of HPLC, LC-MS, and GC-MS assays for biological matrices.
• Impurity Profiling: Employed as a known impurity standard to monitor and control the quality of desipramine active pharmaceutical ingredient (API) during manufacturing.
• Neuroscience Research: A tool compound for studying the structure-activity relationships of tricyclic compounds and their interactions with neurotransmitter transporters.

Basic Information

Product Name	2-Hydroxy Desipramine
CAS No.	1977-15-7
Molecular Formula	C18H22N2O
Molecular Weight	282.38 g/mol
Synonyms	2-Hydroxydesipramine; 10,11-Dihydro-5-[3-(methylamino)propyl]-5H-dibenz[b,f]azepin-2-ol; Desipramine 2-Hydroxy Metabolite; Nor-2-Hydroxyimipramine; 2-OH-Desipramine; 2-Desmethyl-2-hydroxyimipramine; 2-Hydroxy Norimipramine
EINECS	Contact for details

Quality Control

Our 2-Hydroxy Desipramine is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including identification by spectroscopic methods (IR, NMR), purity determination by HPLC, and control of related substances. Certificates of Analysis (COA) detailing all test results are provided to ensure traceability and compliance with your research and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. For long-term storage, consider storing under inert atmosphere to ensure maximum stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.